نتایج جستجو برای: کروموزوم a6
تعداد نتایج: 3185 فیلتر نتایج به سال:
Many monogenic disorders, including the muscular dystrophies, display phenotypic variability despite the same disease-causing mutation. To identify genetic modifiers of muscular dystrophy and its associated cardiomyopathy, we used quantitative trait locus mapping and whole genome sequencing in a mouse model. This approach uncovered a modifier locus on chromosome 11 associated with sarcolemmal m...
Despite the ever-increasing role of pesticides in modern agriculture, their deleterious effects are still underexplored. Here we examine the effect of A6, a pesticide derived from the naturally-occurring α-terthienyl, and structurally related to the endocrine disrupting pesticides anilinopyrimidines, on living zebrafish larvae. We show that both A6 and an anilinopyrimidine, cyprodinyl, decrease...
The human complement component C4 occurs in many different forms which show big differences in their haemolytic activities. This phenomenon seems likely to be of considerable importance both physiologically and pathologically. C4 is coded by duplicated genes between HLA-D and HLA-B loci in the major histocompatibility complex in man. Several fold differences in haemolytic activity between produ...
Purpose: To compare the effect of laminin and gelatin on short-term culture of spermatogonial stem cells (SSCs) from neonatal mouse testes.Materials and Methods: Cell suspension containing SSCs were isolated from testes of 6 day-old mice and cultured in the presence of Glial-derived neuroterophic factor (GDNF), Epidermal Growth Factor (EGF) and Basic Fibroblastic Growth Factor (bFGF) on laminin...
Although respiration is vital to the survival of all mammals from the moment of birth, little is known about the genetic factors controlling the prenatal maturation of this physiological process. Here we investigated the role of the Phox2a gene that encodes for a homeodomain protein involved in the generation of noradrenergic A6 neurons in the maturation of the respiratory network. First, compa...
Using random PCR amplification followed by plasmid subcloning and DNA sequencing, we detected bocavirus related sequences in 9 out of 17 porcine stool samples. Using primer walking, we sequenced the nearly complete genomes of two highly divergent bocaviruses we provisionally named porcine bocavirus 1 isolate H18 (PBoV1-H18) and porcine bocavirus 2 isolate A6 (PBoV2-A6) which differed by 51.8% i...
Int. C. A6 IK38/10 (2006.01) A6 IK38/8 (2006.01) CI2O I/68 (2006.01) A6 IK38/17 (2006.01) GOIN33/50 (2006.01) A61 K38/03 (2006.01) U.S. C. CPC .......... CI2O I/6883 (2013.01); A61K 38/1774 (2013.01); A61 K38/1825 (2013.01); G0IN 33/5023 (2013.01); A61K 38/03 (2013.01); A61 K 38/10 (2013.01); C12O 2600/106 (2013.01); C12O 2600/136 (2013.01); C12O 2600/158 (2013.01); G0IN 2800/304 (2013.01) Fiel...
The RNA recognition motif (RRM) binds to single-stranded RNA target sites of diverse sequences and structures. A conserved mode of base recognition by the RRM involves the simultaneous formation of a network of hydrogen bonds with the base functional groups and a stacking interaction between the base and a highly conserved aromatic amino acid. We have investigated the energetic contribution of ...
A novel recombinant coxsackievirus A6 (CVA6) strain was isolated during a coxsackievirus A6 outbreak in Shanghai, China, in 2013. Genomic sequence and similarity plot analysis showed that the novel CVA6 strain shared higher similarity with a recent CVA4 strain rather than the recent CVA6 strain in the 2C and 3' untranslated regions (UTRs).
A study of the influence of sustained, visual near-work upon a set of oculomotor functions (ZCSV i.e. Zone of Clear Single Vision) was carried out on a randomly drawn group (N = 43) of young, female, healthy and experienced accountants (mean age 24.6 years) who were daily engaged in full-time interactive VDT work. PRA (Positive Relative Accommodation), NRA (Negative Relative Accommodation), PRC...
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