In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-...

Cleft palate following cleft lip may include a developmental disorder during palatogenesis. CL/Fr mice fetuses, which develop cleft lip and palate spontaneously, have less capability for in vivo cell proliferation in palatal mesenchyme compared with CL/Fr normal fetuses. In order to know the changes of signaling molecules contributing to cleft palate morphogenesis following cleft lip, the mRNA ...

basal encephalocele is a rare craniofacial anomaly. in the present paper we report a 10-year-old boy presented with cleft palate, congenital nystagmus, and hypertelorism. during preoperative evaluation for cleft palate repair, a pulsatile mass was detected in the pharynx. magnetic resonance imaging showed sphenoethmoidal type of basal encephalocele and agenesis of corpus callosum. neurosurgical...

OBJECTIVE This study aimed at carrying out a radiographic analysis on the prevalence of dental anomalies of number (agenesis and supernumerary teeth) in permanent dentition, in different subphenotypes of isolated cleft palate preadolescent patients. METHODS Panoramic radiographs of 300 patients aged between 9 and 12 years, with cleft palate and enrolled in a single treatment center, were retr...

background: children with cleft lip and palate generally suffer from inappropriate and inadequate feeding, resulting in insufficient weight gain leading to malnutrition and poor growth. we aimed to evaluate the nutritional and growth status of cleft lip and palate children before and after reconstructive cleft lip and palate surgery. methods: all cleft lip and palate children aging from birth u...

introduction: cleft lips and cleft palates are common congenital abnormalities in children. various chromosomal loci have been suggested to be responsible the development of these abnormalities. the present study was carried out to investigate the association between the suspected genes (methylenetetrahydrofolate reductase [mthfr] a1298c and c677t) that might contribute into the etiology of the...

background: current methods of closure of the cleft palate result in the formation of scars and impairment of growth. distraction osteogenesis (do) might be an effective means to repair or at least reduce the size of wide clefts. this study investigates the biomechanical aspects of this process. materials and methods: do simulation was applied to reduce the size of a unilateral hard palate clef...

Cleft lip and cleft palate has got a high incidence in Asian births. There are different techniques for closure of the cleft. The furlows double opposing Z-plasty repair of cleft palate was first described by Leonard Furlow in 1978. Here we present 2 case of cleft palate treated with Furlows double opposing Zplasty.

BACKGROUND Nasalance is used to evaluate the velopharyngeal incompetence in clinical diagnoses using a nasometer. The aim of this study is to find the nasalance differences between Vietnamese cleft palate children and Korean cleft palate children by measuring the nasalance of five oral vowels. METHODS Ten Vietnamese cleft palate children after surgery, three Vietnamese children for the contro...