background: the wnt/β- the wnt/β-catenin signaling pathway is involved in many developmental processes in both fetal and adult life; its abnormalities can lead to disorders including several types of cancers and malfunction of specific cells and tissues in both animals and humans. its role in reproductive processes has been proven. objective: this study was designed to evaluate the expression o...

Abstract Aberrant Wnt signaling drives a number of cancers through regulation diverse downstream pathways. Wnt/?-catenin achieves this in part by increasing the expression proto-oncogenes such as MYC and cyclins. However, global assessment Wnt-regulated transcriptome vivo genetically distinct demonstrates that suppresses many genes it activates. In study, we examined set are upregulated upon in...

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA methylation such as CDKN2B & p73. Wnt inhibitory factor 1 (WIF1) and Dickkopf-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients. Patients and Methods: ...

Objetivo: Determinar la participación de las vías señalización Wnt en el potencial osteogénico superficie titanio con nanotopografía (Ti-nano) comparadas maquinada.Métodos: Fueron utilizamos discos Ti tratados una solución H2SO4/H2O2 para producir superficies nanotopografía, y sin tratamiento consideraros como control. Luego, células MC3T3-E1, fueron cultivadas ambas evaluar expresión génica re...

Abstract WNT-medulloblastoma has an excellent prognosis, with overall survival rate of 90% among children receiving standard-of-care surgical resection, radiotherapy, and chemotherapy. While curative, this treatment is associated major, long-term, debilitating side effects. Therefore, it crucial we develop effective, less toxic therapies for these children. The Gilbertson lab previously shown t...

Abstract Genotoxic colibactin-producing pks + Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected human CRC, suggesting a causal link. Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. Organoids rec...

background: in acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through dna methylation such as cdkn2b & p73. wnt inhibitory factor 1 (wif1) and dickkopf-3 (dkk-1) are negative regulators of wnt signaling pathway. in the present study, we evaluated the methylation status of wif1 and dkk-1 genes in acute myeloblastic leukemia patients. patients and methods: bloo...