نتایج جستجو برای: ژن ppar gamma

تعداد نتایج: 143241  

Journal: :Nature medicine 2001
A Chawla Y Barak L Nagy D Liao P Tontonoz R M Evans

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is highly expressed in lipid-accumulating macrophages of the coronary artery. In light of this, the wide-spread clinical use of thiazolidinediones (TZDs) in the treatment of type II diabetes raises concerns about the role of PPAR-gamma in macrophage function and disease progression. To define the role of PPAR-gamma in macrophage biol...

Journal: :Indian journal of biochemistry & biophysics 2012
Manju S Devi Perumana R Sudhakaran

Diabetes is associated with increased formation of advanced glycation end products (AGEs), which have been implicated in micro and macrovascular complications of diabetes. Our earlier reports showed proangiogenic effect of AGE-bovine serum albumin (BSA). In order to understand the mechanism of AGE-mediated angiogenesis, the possibility of involvement of peroxisome prolifeator activated receptor...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2003
Jianye Xu Yumei Fu Anping Chen

Hepatic fibrogenesis occurs as a wound-healing process after many forms of chronic liver injury. Hepatic fibrosis ultimately leads to cirrhosis if not treated effectively. During liver injury, quiescent hepatic stellate cells (HSC), the most relevant cell type, become active and proliferative. Oxidative stress is a major and critical factor for HSC activation. Activation of peroxisome prolifera...

Journal: :Journal of the American Society of Nephrology : JASN 2006
Yingjian Li Xiaoyan Wen Bradley C Spataro Kebin Hu Chunsun Dai Youhua Liu

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that plays an important role in the regulation of insulin sensitivity and lipid metabolism. Evidence shows that PPAR-gamma agonists also ameliorate renal fibrotic lesions in both diabetic nephropathy and nondiabetic chronic kidney disease. However, little is known about the mechanism underly...

Journal: :hepatitis monthly 0
mandana mahmoodzadeh sagheb department of biology, science and research branch, islamic azad university, shiraz, ir iran negar azarpira transplant research center, shiraz university of medical sciences, shiraz, ir iran; transplant research center, shiraz university of medical sciences, shiraz, ir iran. tel/fax: +98-711647433 mokhtar mokhtary department of biology, kazeroon branch, islamic azad university, kazeroon, ir iran sayyed ebrahim hosseini department of biology, science and research branch, islamic azad university, shiraz, ir iran ramin yaghobi transplant research center, shiraz university of medical sciences, shiraz, ir iran

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

Journal: :Current stem cell research & therapy 2016
Yunfeng Lin

Peroxisome proliferator-activated receptors (PPARs) are a group of ligand-dependent nuclear receptors responsible for gene expression regulation and function as transcriptional regulators of adipogenic differentiation and lipid metabolism. Members of PPAR family, especially PPAR gamma, are predominantly expressed in adipose tissue and have been demonstrated as important regulators of stem cell ...

Journal: :Hypertension 2003
Ernesto L Schiffrin Farhad Amiri Karim Benkirane Marc Iglarz Quy N Diep

Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors acting as transcription factors on numerous target genes after heterodimerization with the retinoid X receptor. PPAR-alpha and PPAR-gamma may be activated by different agonists, although the endogenous ligands are unknown. Although PPAR-alpha is mainly involved in fatty acid oxidation and expressed in liver, kidney, and sk...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Sung Yong Lee Eun Joo Kang Gyu Young Hur Ki Hwan Jung Hye Cheol Jung Sang Yeub Lee Je Hyeong Kim Chol Shin Kwang Ho In Kyung Ho Kang Se Hwa Yoo Jae Jeong Shim

The main etiologic factor for chronic bronchitis is cigarette smoke. Exposure to cigarette smoke is reported to induce goblet cell hyperplasia and mucus production. Mucin synthesis in airways has been reported to be regulated by the EGFR system. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the ligand-activated nuclear receptor superfamily. PPAR-gamma is implicate...

2010
Saroj K. Mohapatra Amir J. Guri Montse Climent Cristina Vives Adria Carbo William T. Horne Raquel Hontecillas Josep Bassaganya-Riera

BACKGROUND Peroxisome proliferator-activated receptors are nuclear receptors highly expressed in intestinal epithelial cells (IEC) and immune cells within the gut mucosa and are implicated in modulating inflammation and immune responses. The objective of this study was to investigate the effect of targeted deletion of PPAR gamma in IEC on progression of experimental inflammatory bowel disease (...

Journal: :Nephron. Clinical practice 2009
Zhiguo Mao Albert C M Ong

The peroxisome proliferator-activated receptor superfamily (PPARs) comprises a class of nuclear receptors with significant effects in regulating multiple cellular pathways. Much research and clinical interest has surrounded the PPAR-gamma isoform because of its key role in the transcriptional regulation of metabolic pathways and the efficacy of thiazolidinediones, the most clinically used PPAR-...

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