نتایج جستجو برای: ژن pel
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In [4] a nonmonotonic formalism called partial equilibrium logic (PEL) was proposed as a logical foundation for the well-founded semantics (WFS) of logic programs. PEL consists in de ning a class of minimal models, called partial equilibrium (p-equilibrium), inside a non-classical logic called HT 2. In [4] it was shown that, on normal logic programs, p-equilibrium models coincide with Przymusin...
Primary effusion lymphoma (PEL) is an aggressive and rare malignancy predominantly occurring in patients with HIV infection and severe immunodeficiency. PEL has also been reported in recipients of solid organ transplants and in elderly patients in the absence of immunodeficiencies. PEL is a distinct subtype of B-cell non-Hodgkin lymphoma (NHL) characterized by lymphomatous effusions within majo...
PEL is a B-cell non-Hodgkin lymphoma, occurring predominantly as a lymphomatous effusion in body cavities, characterized by aggressive clinical course, with no standard therapy. Based on previous reports that PEL cells display a Warburg phenotype, we hypothesized that the highly hypoxic environment in which they grow in vivo makes them more reliant on glycolysis, and more vulnerable to drugs ta...
Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts to identify novel approaches to block proliferation of PEL cells, we found that sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell proliferation and induces apoptosis in a dose-dependent manner in s...
A formalism called partial equilibrium logic (PEL) has recently been proposed as a logical foundation for the well-founded semantics (WFS) of logic programs. In PEL one defines a class of minimal models, called partial equilibrium models, in a non-classical logic, HT . On logic programs partial equilibrium models coincide with Przymusinski’s partial stable (p-stable) models, so that PEL can be ...
The administration of an aqueous-ether extracted residue of Brucella abortus (Bru-Pel) inhibits development of transplanted osteogenic sarcomas in mice as evidenced by a decrease in mortality. At least one mechanism through which Bru-Pel modulates host resistance is activation of macrophages of the reticuloendothelial system. Peritoneal macrophages harvested from mice receiving Bru-Pel were cyt...
Primary effusion lymphoma (PEL) is a diffuse-large B-cell lymphoma with poor prognosis. One hundred percent of PELs carry the genome of Kaposi sarcoma-associated herpesvirus and a majority are coinfected with Epstein-Barr virus (EBV). We profiled genomic aberrations in PEL cells using the Affymetrix 6.0 SNP array. This identified for the first time individual genes that are altered in PEL cells...
Primary effusion lymphoma (PEL) caused by Kaposi's sarcoma-associated herpesvirus (also known as human herpesvirus-8) shows serious lymphomatous effusion in body cavities. PEL is difficult to treat and there is no standard treatment strategy. Hippuristanol is extracted from Okinawan coral Isis hippuris, and inhibits translational initiation by blocking eukaryotic initiation factor 4A, an ATP-de...
Certain lymphomas in AIDS patients, such as primary effusion lymphoma (PEL), are closely associated with the lymphotropic gamma herpes virus Kaposi's sarcoma-associated herpes virus (KSHV), also called human herpesvirus 8. The virus is thought to be essential for tumorigenesis, yet systems to investigate PEL in vivo are rare. Here we describe PEL tumorigenesis in a new xenograft model. Embedded...
We constructed strains of Erwinia chrysanthemi EC16 with multiple mutations involving three virulence systems in this bacterium, namely pel (coding for the major pectate lyases pelABCE), hrp (hypersensitive response and pathogenicity), and sap (sensitivity to antimicrobial peptides). The relative effects on virulence of those mutations have been analyzed on potato tubers and chicory leaves. In ...
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