AbstractIn the health sector, pharmaceutical preparations and medical devices that will be circulated to public as well authorities in use of these must guaranteed safety order ensure do not endanger users. However, practice legal problems arise where there is a circulation rapid test equipment does have distribution permit. The purpose this study was find out whether act distributing without p...

tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been identified. downless (Dl) encodes Edar, a novel member of the tumour necrosis factor (TNF) receptor family, containing the characteristic extracellular cysteine rich fold, a single transmembrane region and a death homology domain...

A subgroup of the TNF receptor family, composed of Edar, Troy and Xedar, are implicated in the development of ectodermal appendages, such as hair follicles, teeth and sweat glands. We have isolated chicken orthologues of these three receptors and analysed their roles in early feather development. Conservation of protein sequences between mammalian and avian proteins is variable, with avian Edar...

It is widely accepted that evolutionary changes in conserved developmental signaling pathways play an important role in morphological evolution. However, few in silico studies were interested in tracking such changes in a signaling pathway. The Ectodysplasin (EDA) pathway provides an opportunity to fill this gap because it is involved in vertebrate skin appendage development such as scales, tee...

AbstractThe circulation of candy with tadalafil content in the community needs a serious attention by BPOM. The product that is circulating closely related to distribution permit. has not been registered BPOM because it listed list drugs already have permission from manufacturer or importer and must be examined legal status product. This study tries explain legality products extent BPOM's respo...

Desmosomes are cell adhesion junctions required for the normal development and maintenance of mammalian tissues and organs such as the skin, skin appendages, and the heart. The goal of this study was to investigate how desmocollins (DSCs), transmembrane components of desmosomes, are regulated at the transcriptional level. We hypothesized that differential expression of the Dsc2 and Dsc3 genes i...