نتایج جستجو برای: ژن cyp1b1

تعداد نتایج: 16752  

Journal: :Cancer research 2004
Yuki Tsuchiya Miki Nakajima Satoru Kyo Taro Kanaya Masaki Inoue Tsuyoshi Yokoi

Human cytochrome P450 (CYP) 1B1 is a key enzyme in the metabolism of 17beta-estradiol (E2). CYP1B1 is mainly expressed in endocrine-regulated tissues, such as mammary, uterus, and ovary. Because many CYP enzymes are likely to be induced by the substrates themselves, we examined whether the human CYP1B1 expression is regulated by E2 in the present study. Real-time reverse transcription-PCR analy...

2016
Chi Young Song Khuzema Ghafoor Hafiz U. Ghafoor Nayaab S. Khan Shyamala Thirunavukkarasu Brett L. Jennings Anne M. Estes Sahar Zaidi Dave Bridges Patrick Tso Frank J. Gonzalez Kafait U. Malik

Cytochrome P450 (CYP) 1B1 contributes to vascular smooth muscle cell growth and hypertension in male mice. This study was conducted to determine the contribution of CYP1B1 to the development of atherosclerosis and hypertension and associated pathogenesis in 8-week-old male apolipoprotein E-deficient (ApoE(-/-)/Cyp1b1(+/+)), and ApoE- and CYP1B1-deficient (ApoE(-/-)/Cyp1b1(-/-)) mice fed a norma...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2009
Simone Helmig Bahar Hadzaad Juliane Döhrel Joachim Schneider

Cytochrome P450 1B1 (CYP1B1), a phase I enzyme, is involved in the activation of a broad spectrum of procarcinogens. An association of the Cyp1B1 L432V polymorphism with diverse types of cancer, as well as an impact on the catalytic activity of the enzyme, has been described. To show the functional impact of the allelic variant Cyp1B1*3, we investigated the quantitative Cyp1B1 mRNA expression i...

2016
Cheng-Yuan Gu Xiao-Jian Qin Yuan-Yuan Qu Yu Zhu Fang-Ning Wan Gui-Ming Zhang Li-Jiang Sun Yao Zhu Ding-Wei Ye

Clinically localized prostate cancer is curative. Nevertheless many patients suffered from biochemical recurrence (BCR) after radical prostatectomy (RP). Mounting evidence suggest that estrogen and xenobiotic carcinogens play an essential role in progression of prostate cancervia oxidative estrogen metabolism. CYP1B1 is an enzyme involved in the hydroxylation of estrogens, a reaction of key rel...

2009
Yixin Tang Elizabeth A. Scheef Shoujian Wang Christine M. Sorenson Craig B. Marcus Colin R. Jefcoate Nader Sheibani

Reactive species derived from cell oxygenation processes play an important role in vascular homeostasis and the pathogenesis of many diseases including retinopathy of prematurity. We show that CYP1B1-deficient (CYP1B1 / ) mice fail to elicit a neovascular response during oxygen-induced ischemic retinopathy. In addition, the retinal endothelial cells (ECs) prepared from CYP1B1 / mice are less ad...

Journal: :The Journal of biological chemistry 2014
Seema Bansal Adrian N Leu Frank J Gonzalez F Peter Guengerich Anindya Roy Chowdhury Hindupur K Anandatheerthavarada Narayan G Avadhani

We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Site-directed mutagenesis, COS-7 cell transfection, and in vitro import studies in isolated mitochondria showed that a positively charged domain at residues 41-48 of h...

Journal: :Cancer research 1998
M C Larsen W G Angus P B Brake S E Eltom K A Sukow C R Jefcoate

CYP1B1 and CYP1A1 expression and metabolism of 7,12-dimethylbenz(a)anthracene (DMBA) have been characterized in early-passage human mammary epithelial cells (HMECs) isolated from reduction mammoplasty tissue of seven individual donors. The level of constitutive microsomal CYP1B1 protein expression was donor dependent (<0.01-1.4 pmol/mg microsomal protein). CYP1B1 expression was substantially in...

2006
David L. Alexander Sakina E. Eltom Colin R. Jefcoate

Cytochrome P4S01B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites. The C3H mouse embryo fibroblast cell line, C3H10T1/2, and primary mouse embryo fibroblasts (MEFs) express CYP1B1 as the predominant cytochrome P450 form. This is constitutively expressed and induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but also, to a greater ext...

Journal: :International journal of oncology 2009
Wataru Habano Toshie Gamo Tamotsu Sugai Koki Otsuka Go Wakabayashi Shogo Ozawa

Cytochrome P450 (CYP) 1A1 (CYP1A1) and CYP1B1, dioxin-inducible CYP1s, are associated with carcinogenesis in extrahepatic tissues. CYP1B1 is featured in carcinogenesis of hormone-responsive tissues, where the CYP1B1 level is considerably high. Although aberrant expression of these enzymes is also observed in cancers that are not related to hormone response, their roles in carcinogenesis are not...

Journal: :Blood 2009
Yixin Tang Elizabeth A Scheef Shoujian Wang Christine M Sorenson Craig B Marcus Colin R Jefcoate Nader Sheibani

Reactive species derived from cell oxygenation processes play an important role in vascular homeostasis and the pathogenesis of many diseases including retinopathy of prematurity. We show that CYP1B1-deficient (CYP1B1(-/-)) mice fail to elicit a neovascular response during oxygen-induced ischemic retinopathy. In addition, the retinal endothelial cells (ECs) prepared from CYP1B1(-/-) mice are le...

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