BACKGROUND From 2006 to 2011, biological activity of insecticides for Indoor Residual Spraying (IRS), conventional treatment of nets (CTNs) or long lasting insecticidal nets (LLINs) was evaluated before their approval in Cameroon. The objective of the study was to select the best tools for universal malaria vector control coverage. METHODOLOGY Bioassays were performed using WHO cones and the ...

Cardiac troponin-I (cTnI) and -T (cTnT) are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention (PCI)-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT (cTns) in PCI-related...

Objective: Cystinosis is a rare, autosomal recessive, lysosomal storage disorder characterized by cystine accumulation throughout the body, due to mutations in gene encoding cystinosin, named CTNS. Infantile nephropathic cystinosis (INC), most severe form of disease and common cause renal Fanconi syndrome (FS), starts with proximal tubulopathy causes failure various extra-renal manifestations o...

OBJECTIVES To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired. We also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory. METHODS Different MGEs, including two conjugative transposons (CTns) of the Tn916 fami...

Polynuclear transition metal complexes such as the P-cluster and FeMo-cofactor of nitrogenase with eight centers represent a great challenge for current electronic structure methods. In this work, we initiated use comb tensor network states (CTNS), whose underlying topology has one-dimensional backbone several branches, many-body wavefunction ansatz to tackle these challenging systems. As an im...

Cardiac troponins (cTns) are sensitive and specific biomarkers for myocardial injury and are widely used in daily clinical practice. In patients presenting with acute coronary syndrome (ACS), cTns allow rapid risk stratification and are critical components of further patient management. Because of the large clinical and pathophysiological overlap of cardiovascular and cerebrovascular disease an...

Abstract In the freight transport sector, competing companies horizontally collaborate through establishing Collaborative Transport Networks (CTNs). Fruitful implementation of CTNs will leverage environmental and socio-economic goals sustainable development in sector. The benefits horizontal collaborative settings have been widely demonstrated several modelling approaches. However, practice, re...

OVERVIEW Overall, the project produced some insightful and intriguing results. The project was designed to further delineate the Ctns-/macrophage phenotype both in vitro (Aim 1) and confirming these phenotypic findings in vivo in the context of chronic kidney injury (Aim 2). The project progressed as expected for Aim 1 but we were confounded by the results from Aim 2. As discussed below, we fou...

The aim of the project “Small molecule regulators of vesicular trafficking to enhance lysosomal exocytosis in cystinosis” is to use strategies directed at upregulating the exocytic pathway in cystinotic cells, in order to improve vesicular transport, force cystine release and restore normal cell function. Our hypothesis, in fact, states that cells that have accumulated cystine share the intrace...