The small G protein Ras is a central regulator of cellular signal transduction processes, functioning as a molecular switch. Switch mechanisms utilizing conformational changes in nucleotide-binding motifs have been well studied at the molecular level. Azobenzene is a photochromic molecule that undergoes rapid and reversible isomerization between the cis and trans forms upon exposure to ultravio...

A series of nitrogen-doped carbons (NCs) were prepared by the pyrolysis (300–900 °C) crystalline polyazomethine (PAM) synthesized via a facile condensation reaction in methanol solvent. The controlled solvent evaporation resulted PAM crystals form nanosheet clusters with sheet thickness ~50 nm. Such architecture was maintained after pyrolysis, obtaining porous CNs high specific surface areas up...

PURPOSE To evaluate clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma. METHODS Retrospective chart review and Kaplan-Meier estimates of times to PAM enlargement, recurrence, and transformation into melanoma. MAIN OUTCOME MEASURES PAM enlargement, recurrence, and transformation into melanoma. RESULTS The mean patient age at diagno...

Deep ripping, in conjunction with gypsum and/or organic amendment, is known to be useful for removing physical constraints and improving crop yields dispersive subsoils. However, the benefits are short-lived due lateral movement of Na into soil between rip lines, slumping following wetting loosened soil, leaving low pore volume air water movement. This study evaluated effect high concentration ...

Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into...

A decade of visual and acoustic detections of marine megafauna around offshore Oil & Gas (O&G) installations in the North and Irish Seas are presented. Marine megafauna activity was monitored visually and acoustically by Joint Nature Conservation Committee (JNCC) qualified and experienced Marine Mammal Observers (MMO) and Passive Acoustic Monitoring (PAM) Operators respectively, with real-time ...

BACKGROUND Primary amoebic meningoencephalitis (PAM) is a fulminant disease of the brain caused by Naegleria fowleri. Although the disease is rare, the case fatality rate is very high. In this report, we describe the first case of PAM in Zambia. CASE PRESENTATION The patient presented with sudden onset of seizures and fever on admission. On physical examination he was febrile, comatose and wi...

OBJECTIVE (1) To compare clinical characteristics of patients with psoriatic arthritis (PsA) with PsA mutilans (PAM) and without PAM, and (2) to determine the rate of PAM radiographic progression. METHODS A retrospective cohort study was conducted of all patients with PsA attending a teaching hospital. The most recent hand and feet radiographs were screened for PAM. Serial radiographs (earlie...