The toxicity of preservatives on conjunctival epithelium has been widely described in glaucomatous patients topically treated, suggesting both an indirect effect on the lacrimal film and a direct toxic action on epithelial cells (1). Previous studies indicate that long-term administration of preservative-containing eyedrops can lead to chronic conjunctival inflammation, ocular surface impairmen...

1 Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK 2 Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neuroscience, University College London, London WC1N 1PJ, UK 3 Wellcome Department of Imaging Neuroscience, UCL Institute of Neurology, University College London WC1N 3BG, UK 4 Section of Neurology, ...

áeñ = 2.22 in the infiltrated one (reducing the contrast at the same time). After inversion the mean dielectric constant decreases to áeñ = 1.41 and, accordingly, the L pseudogap energy shifts upwards (see Fig. 5). The peak width is a function of both the dielectric contrast and the filling factor of the structure. Bare opals present a contrast eSiO2/eair = 2.1 that shifts to epolymer/eSiO2 = 1...

In bacterial chemotaxis, an assembly of transmembrane receptors, the CheA histidine kinase and the adaptor protein CheW processes environmental stimuli to regulate motility. The structure of a Thermotoga maritima receptor cytoplasmic domain defines CheA interaction regions and metal ion–coordinating charge centers that undergo chemical modification to tune receptor response. Dimeric CheA–CheW, ...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285 4.8 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349 5.9 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 6.8 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387 6.5 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....