Functional mitral regurgitation (FMR) is frequent in patients with heart failure (HF). It develops as a consequence of left ventricle (LV) geometry alterations, causing imbalance between increased tethering forces and decreased closing forces exerted on the mitral valve apparatus during systole.FMR is known to change at rest and during effort, due to preload-afterload changes, myocardial ischem...

Shrews (genus Sorex, small insectivorous mammals) are well known for their extremely high basal metabolic rates (BMRs) even when corrected for their small body size. We measured energy expenditure of the common shrew (Sorex araneus) under natural conditions (field metabolic rate [FMR]) by doubly labeled water method to test whether FMR is proportional to high BMR in this species. The study was ...

BACKGROUND AND PURPOSE Functional MR (fMR) imaging is based on changes in regional blood flow. The purpose of this study was to evaluate the role of fMR imaging for detection of a vascular compromised status in the occipital lobe in patients with ischemia in the visual cortex. METHODS We performed fMR imaging in seven control subjects and seven patients with symptoms and signs of visual corti...

Nanocrystalline Co2MnSi Heusler alloy films were deposited on the PZN-PT substrates by a composition gradient sputtering method. It is revealed that this multiferroic heterostructure shows very strong magnetoelectric coupling, leading to continuously tunable microwave frequency characteristics by electric field. With the increase of electric field intensity from 0 to 6 kV/cm, the magnetic aniso...

BACKGROUND Patients with aortic stenosis (AS) treated with aortic valve replacement (AVR) may also present with associated functional mitral valve regurgitation (FMR). Whether to also address the mitral valve at the time of AVR remains unclear. This study was designed to determine the influence of MR on survival and its evolution over time. METHODS We retrospectively reviewed 74 patients with...

Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactiv...

BACKGROUND Physical activity (PA) is a key intervention for chronic disease, yet few physicians provide exercise prescription (EP). EP is an important component in larger strategies of reducing non-communicable disease (NCD). Our objective was to assess Family Medicine Residents (FMR) knowledge, competence, and perspectives of EP to help inform future curriculum development. METHODS A 49-item...

Murray M. Humphries,* Stan Boutin, Donald W. Thomas, John D. Ryan, Colin Selman, Andrew G. McAdam, Dominique Berteaux and John R. Speakman Abstract There is renewed focus on the ecological determinants of animal metabolism and recent comparative analyses support the physiological expectation that the field metabolic rate (FMR) of homeotherms should increase with declining ambient temperature. H...