Congenital heart defects contribute to embryonic or neonatal lethality but due to the complexity of cardiac development, the molecular changes associated with such defects are not fully understood. Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development. Brn-3a directly represses Brn-3b promoter in cardiomyocytes and cons...

Disclosures: M.D. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.M. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. M.G. Hamming: None. M.B. Ellman: None. T.L. Turnbull: None. M.T. Rasmussen: None. R.F. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.A. Wijdicks: 5; Acumed, AlloSource, Arthrex, Biomet, Ceterix Orthopaedics, ConMed Linvatec, DePuy Synthes, OREF, Ossur, Smith & Nephew,...

WEHI-3B/NOVO is a cloned murine leukemia cell line selected for resistance to novobiocin that is cross-resistant to the cytotoxic action of etoposide (VP-16) and to a lesser extent to a variety of other topoisomerase II (topo II)-reactive drugs. We have reported previously (Cancer Res. 52: 2782-2790, 1992) that WEHI-3B/NOVO cells exhibit a pronounced decrease in VP-16 induced DNA-topo II cross-...

Brucella abortus releases two components (fractions 3b and 10) that inhibit the myeloperoxidase-H2O2-halide antibacterial system of bovine neutrophils by inhibiting degranulation. Fractions 3b and 10 were analyzed by high-performance liquid chromatography and thin-layer chromotography and compared with nucleotide and base standards. These investigations indicated that fraction 3b coeluted and c...

The crystal structure of the homodimer formed by the tritolylurea 3a proves the existence of a belt of six bifurcated hydrogen bonds between both NH and the O=C groups of the adjacent urea residues. For the tritosylurea 3b, four additional three-center hydrogen bonds, also involving the SO2 oxygen, are found in the crystalline state. Molecular dynamics simulations in a chloroform box confirm th...

The short arm of chromosome 3 has been shown to exhibit high loss of heterozygosity in several types of cancer including ovarian, kidney, lung, and testicular cancers. In particular, overlapping homozygous deletions in lung cancers have been identified in region 3p21.3. Semaphorin 3B, a gene that resides within this region, has been proposed to be involved in tumorigenesis. To address this hypo...

  Although each subdivision of primary somatosensory cortex (SI) receives dense input from the thalamus, but the exact location and type of information that the fibers convey have not been identified yet. In the present study, the exact source of thalamocortical fibers to areas 2 and 3b was investigated using tract-tracing techniques. Following injection of tracer into area 3b, labeled neurons ...

s : Pyothorax-associated lymphoma (PAL) is an EBV-associated lymphoma, which develops in the pleural cavity of immunocompetent patients with an over-20-year history of pyothorax. PAL tumor cells taken from a 72-year-old man revealed having mismatch repair (MMR) phenotype and expression of all Epstein-Barr virus latent genes except EBNA-3B. EBNA-3B gene in the derived cell line had frameshift mu...