We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph no...

GES-type enzymes belong to Ambler Class A plasmidencoded -lactamases. Although GES enzymes usually exhibit extended-spectrum -lactamases (ESBL) properties, changes in its active site enhance its activity conferring the ability to hydrolyze carbapenems.1 GES-type carbapenemases (GES2, GES-4, GES-5, GES-8, GES-11, GES-18, GES-20) have already been described in several countries.2 Although it has ...

Sterigmatocystin (ST), which is commonly detected in food and feed commodities, is a mutagenic and carcinogenic mycotoxin that has been recognized as a possible human carcinogen. Our previous study showed that ST can induce G2 phase arrest in GES-1 cells in vitro and that the MAPK and PI3K signaling pathways are involved in the ST-induced G2 arrest. It is now widely accepted that DNA damage pla...

The monoterpene fraction of the lemon-scented sweet basil (Ocimum basilicum) cv Sweet Dani consists mostly of citral (a mixture of geranial and neral), with lower levels of geraniol and nerol. These compounds are stored in the peltate glands found on the leaf epidermis. Younger leaves, which have a higher density of such glands, also have a higher content of monoterpenes than older leaves. Gera...

u u KNAPOVA' and BRUCKNER (1927).-Casop. lIk. Cesk., Vol. LXVI, p. 1657. KOTSUKA (1937).-Zentralbl. f. d. ges. Ophthal., Vol. XXXIX, p. 317. PASTORE.-SOC. Oftal. Ital. 1925; Zentralbi. f. d. ges. Ophthal., Vol. XVII, p. 522. Russo.-Rass. Ital. Oftal., Vol. VI, p. 72, 1937; Zenttralbl. f. d. ges. Ophthal., Vol. XLI, p. 279. SALUS (1917).-Wiet. klin. Wochenschr., p. 1472. VOGT (1929).-Klin. Monat...

|We introduce the generalized evolutionary spectrum (GES) as a family of time-varying power spectra for nonstationary random processes. The GES extends the well-known evolutionary spectrum and the recently de ned transitory evolutionary spectrum. A particularly interesting member of the GES family is the novel Weyl spectrum. We discuss the properties of the Weyl spectrum, and we apply the Weyl ...

Klebsiella pneumoniae strain KG525, which showed high-level resistance to broad-spectrum cephalosporins, was isolated from the neonatal intensive care unit (NICU) of a Japanese hospital in March 2002. The ceftazidime resistance of strain KG525 was transferable to Escherichia coli CSH-2 by conjugation. Cloning and sequence analysis revealed that production of a novel extended-spectrum class A be...

Rad, Gem/Kir, and mRem (RGK) represent a unique GTPase family with largely unknown functions (Reynet, C., and C.R. Kahn. 1993. Science. 262:1441-1444; Cohen, L., R. Mohr, Y. Chen, M. Huang, R. Kato, D. Dorin, F. Tamanoi, A. Goga, D. Afar, N. Rosenberg, and O. Witte. Proc. Natl. Acad. Sci. USA. 1994. 91:12448-12452; Maguire, J., T. Santoro, P. Jensen, U. Siebenlist, J. Yewdell, and K. Kelly. 199...

This study determined the most efficient parameters of low-frequency/long-pulse gastric electrical stimulation (GES) required to entrain gastric slow waves and also evaluated the effect of entrainment and high-frequency, short-pulse GES on gastric electrical activity (GEA). Nine dogs were fitted with stimulation wires along the greater curvature. Entrainment was observed in six or seven animals...