G protein-activated inwardly rectifying potassium (GIRK) channels mediate slow synaptic inhibition and control neuronal excitability. It is unknown whether GIRK channels are subject to regulation by guanine dissociation inhibitor (GDI) proteins like LGN, a mammalian homolog of Drosophila Partner of Inscuteable (mPINS). Here we report that LGN increases basal GIRK current but reduces GIRK activa...

1 يوجشناد سانشراک ی ،هیذغت مولع دشرا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ناریا 2 لوئسم هدنسیون : هورگ رایداتسا هیذغت هعماج ،ناریا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ، یکینورتکلا تسپ : [email protected] 3 داتسا هورگ هیذغت هعماج هدکشناد، هیذغت میژرو هاگشناد،ینامرد مولع یکشزپ ،نارهت ناریا 4 يارتکد تملاس تاقیقحت یلم وتیتسنا ،ناهفصا یتشادهب ت...

Spindle positioning is believed to be governed by the interaction between astral microtubules and the cell cortex and involve cortically anchored motor protein dynein. How dynein is recruited to and regulated at the cell cortex to generate forces on astral microtubules is not clear. Here we show that mammalian homologue of Drosophila Pins (Partner of Inscuteable) (LGN), a Gαi-binding protein th...

Asymmetric cell division requires the establishment of cortical cell polarity and the orientation of the mitotic spindle along the axis of cell polarity. Evidence from invertebrates demonstrates that the Par3/Par6/aPKC and NuMA/LGN/Gαi complexes, which are thought to be physically linked by the adaptor protein mInscuteable (mInsc), play indispensable roles in this process. However, the molecula...

Classic studies of lateral geniculate nucleus (LGN) and visual cortex (V1) in carnivores and primates have found that a majority of neurons in LGN exhibit a center-surround organization, while V1 neurons exhibit strong orientation selectivity and, in many species, direction selectivity. Recent work in the mouse and the monkey has discovered previously unknown classes of orientation- and directi...

Guanylin and uroguanylin compose a family of natriuretic, diuretic, and kaliuretic peptides that bind to and activate apical membrane receptor guanylyl cyclase signaling molecules in renal and intestinal epithelia. Recently, a complementary DNA encoding an additional member of the guanylin family of cGMP-regulating peptides was isolated from lymphoid tissues of the opossum and was termed lympho...