objective: nucleostemin (ns) is a recently identified gene that is expressed mainly in the nucleoli of neuronal, embryonic and mesenchymal stem cells which plays a role in their self renewal. over expression of this gene has been reported in several cancer cell lines tumoral tissues including gastric, hepatic and prostate cancer. in this study, we investigated the effects of suppression of this...

RNAi-mediated gene therapy is gradually becoming a conventional approach for the treatment of various diseases. One major challenges clinical translation RNAi to efficiently deliver siRNA into targeted tissues and cells. Herein, in article number 20200026 Yiyun Cheng, Jia Lv their co-workers have reviewed recent advances design functional polymers overcome multiple extracellular intracellular b...

Abstract Sex determination is a key developmental event in all organisms. The pathway that regulates sexual fate has been well characterized at the molecular level model free-living nematode Caenorhabditis elegans . This study aims to gain preliminary understanding of sex-determining pathways plant-parasitic Meloidogyne incognita , and extent which roles sex genes are conserved hermaphrodite sp...

background: the most important virulence factor which plays a central role in candida albicans pathogenesis is the ability of this yeast to alternate between unicellular yeast and filamentous hyphal forms. efg1 protein is thought to be the main positive regulating transcription factor, which is responsible for regulating hyphal-specific gene expression under most conditions. als3 is one of the ...

The Caenorhabditis elegans nuclear RNA interference defective (Nrde) mutants were identified by their inability to silence polycistronic transcripts in enhanced RNAi (Eri) mutant backgrounds. Here, we report additional nrde-3-dependent RNAi phenomena that extend the mechanisms, roles, and functions of nuclear RNAi. We show that nrde-3 mutants are broadly RNAi deficient and that overexpressing N...

Despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. A large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. A variety of techniques...