نتایج جستجو برای: مدل coup

تعداد نتایج: 121604  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Zhao Xu Songtao Yu Chung-Hsin Hsu Jun Eguchi Evan D Rosen

The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; Nr2f2) is expressed in adipose tissue in vivo and declines during differentiation. Overexpression of COUP-TFII prevents adipogenesis, whereas shRNA-mediated reduction of COUP-TFII promotes differentiation, as shown by increased lipid accumulation and elevated expression of fat cell marker protein...

Journal: :PLoS Biology 2008
Schoen W Kruse Kelly Suino-Powell X. Edward Zhou Jennifer E Kretschman Ross Reynolds Clemens Vonrhein Yong Xu Liliang Wang Sophia Y Tsai Ming-Jer Tsai H. Eric Xu

The chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and II) make up the most conserved subfamily of nuclear receptors that play key roles in angiogenesis, neuronal development, organogenesis, cell fate determination, and metabolic homeostasis. Although the biological functions of COUP-TFs have been studied extensively, little is known of their structural features or aspects ...

2010
Celina Montemayor Oscar A. Montemayor Alex Ridgeway Feng Lin David A. Wheeler Scott D. Pletcher Fred A. Pereira

BACKGROUND Identification of bona fide direct nuclear receptor gene targets has been challenging but essential for understanding regulation of organismal physiological processes. RESULTS We describe a methodology to identify transcription factor binding sites and target genes in vivo by intersecting microarray data, computational binding site queries, and evolutionary conservation. We provide...

Journal: :Development 2010
Ke Tang Xin Xie Joo-In Park Milan Jamrich Sophia Tsai Ming-Jer Tsai

Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development. The establishment of dorsal/ventral polarity, especially dorsal specification in the optic vesicle, is poorly understood at a molecular and cellular level. Here, we show that COUP-TFI (Nr2f1) and COUP-TFII (Nr2f2) are highly expressed in the progenitor cells in the devel...

Journal: :iranian journal of child neurology 0
andrew m. allmendinger 1. the department of radiology, brigham and women’s hospital, harvard medical school, boston, ma, usa joseph a. ricci 2. the division of plastic surgery, brigham and women’s hospital, harvard medical school, boston, ma, usa naman s. desai 1. the department of radiology, brigham and women’s hospital, harvard medical school, boston, ma, usa narayan viswanadhan 1. the department of radiology, brigham and women’s hospital, harvard medical school, boston, ma, usa diana rodriguez 3. the division of neuroradiology, boston children’s hospital, harvard medical school, boston, ma, usa

how to cite this article: allmendinger am, ricci ja, desai ns, viswanadhan n, rodriguez d. atypical neuroimaging manifestations of linear scleroderma “en coup de sabre”. iran j child neurol. summer 2015;9(3):62-68. abstract linear scleroderma “en coup de sabre” is a subset of localized scleroderma with band-like sclerotic lesions typically involving the fronto-parietal regions of the scalp. pat...

2007
AARON BELKIN EVAN SCHOFER

Although coup risk plays an important role in theories of war, revolution, and democratization, scholars have not developed a rigorous conceptualization and valid measure of the concept. We develop a structural understanding of coup risk as distinct from proximate causes of coups as well as coup-proofing strategies that regimes implement to avert coups. Theoretical insights into factors that pr...

Journal: :Nucleic acids research 1990
H H Ritchie L H Wang S Tsai B W O'Malley M J Tsai

Two different genomic genes for the COUP-transcription factor, COUP-TF I and COUP-TF II, have been isolated from a human cosmid genomic library using a [32P]-labeled cDNA probe. Data obtained from Southern blot analysis of these cosmid clones indicated that two closely related genes exist in the human genome and have a similar genomic organization. The genes are similar in the hormone and DNA b...

Journal: :Cancer research 2004
Roya Navab Juana Maria Gonzalez-Santos Michael R Johnston Jiang Liu Pnina Brodt Ming-Sound Tsao Jim Hu

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays an essential role in angiogenesis and development. It is differentially expressed in tumor cell lines, but its role in carcinogenesis is largely unknown. We demonstrate here that noninvasive human lung cancer cells become invasive when COUP-TFII was expressed. The expression of extracellular matrix degrading proteinas...

Journal: :The Journal of clinical investigation 2016
Xin Xie Sophia Y Tsai Ming-Jer Tsai

Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the disease's pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperact...

Journal: :Mechanisms of Development 1995
Timothy J. Schuh David Kimelman

Isomers of retinoic acid are considered likely regulators of developmental pattern formation in vertebrate embryos. The orphan receptor COUP-TFI, which can alter cellular responses to retinoic acid in cultured cells, is expressed in distinct regions of the developing zebrafish and mouse anterior central nervous system. We asked if COUP-TFI can modulate retinoic acid signaling and anterior neura...

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