Incidence of prescription opioid abuse and overdose, often led by oxycodone, continues to increase, producing twice as many overdose deaths as heroin. Surprisingly, preclinical reports relevant to oxycodone's abuse-related effects are relatively sparse considering its history and patient usage. The goal of this study was to characterize dose- and time-dependent effects of acute and repeated oxy...

Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive ingredient of marijuana, has led to equivocal results when tested with the intracranial self-stimulation (ICSS) procedure or the open-field test for motor activity, two behavioural models for evaluating the reward-facilitating and locomotor stimulating effects of drugs of abuse, respectively. Therefore, in the present study, the effect...

The present study sought to examine whether repeated administration of the CB(1) receptor agonist WIN55,212-2 affected intracranial self-stimulation (ICSS) behavior and induced phenomena of tolerance or sensitization, similar to typical addictive drugs. Rats received intraperitoneal injections of vehicle for 5 days, vehicle or WIN55,212-2 (0.1, 0.3 or 1mg/kg) for 20 subsequent days, and vehicle...

Data on the ability of Delta 9-tetrahydrocannabinol (THC) to modify reward processes in experimental animals are inconsistent. This study examined the effects of Delta 9-THC on brain reward function using the rate-frequency curve shift paradigm of intracranial self-stimulation (ICSS) and the conditioned place preference (CPP) paradigm. In ICSS tests, rats were implanted with electrodes into the...

Context. Integrated control systems (ICSs) are heterogeneous systems where software and hardware components are integrated to control and monitor physical devices and processes. A family of ICSs share the same software code base, which is configured differently for each product to form a unique installation. Due to the complexity of ICSs and inadequate automation support, product configuration ...

Industrial systems present security risk factors related to their cyber vulnerabilities. These spread out over the world, continue be targets of attacks. While industrial share common vulnerabilities with Information Technology (IT) systems, they tend have more constraints due interaction between and physical systems. Intrusion detection give visibility system are considered one solutions detec...

In terms of cyber security metrics, ICSs tend to have unique features: in many cases, these systems are older technologies that were designed for functionality rather than security. They are also extremely diverse systems that have different requirements and objectives. Therefore, metrics for ICSs must be tailored to a diverse group of systems with many features and perform many different funct...