BACKGROUND/AIM Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both agents show cytotoxicity toward T-cell malignancies. In the present study, we...

در این مقاله، به بررسی اثر پارامترهای کاری گوناگون بر شکل تپ‌های خروجی یک لیزر 2CO تپی فشار اتمسفری پرتکرار دست‌ساز (با آهنگ تکرار تا kHz 1) پرداخته شده است. راستا، عوامل گوناگونی هم­چون: نسبت گاز 2N، He و بازتابندگی آینه جلویی تغییر داده شدند انرژی گسیلی هر از حالت‌ها ثبت مشخصه‌یابی شدند. نشان شد که با گازهای 2N He، می‌توان دیرش زمانی میخه دنباله‌ی تپ‌ها را بازه‌ی ns 140-95 µs 5/3-5/1 تنظیم نم...

Contagious equine metritis (CEM) is a highly contagious bacterial venereal disease of horses caused by Taylorella equigenitalis. CEM-PCR is a semi-nested PCR method for detecting this bacterium. Although this technique is regarded as a sensitive diagnostic method for CEM, there are risks of it generating false positive and false negative results. In this study, we constructed a recombinant plas...

INTRODUCTION Numerous studies suggest that total cholesterol content of erythrocyte membranes (CEM) might play a critical role in atherosclerotic plaque progression and instability. However, the exact role of CEM in atherosclerosis remains obscure. Our study was designed to investigate the association between CEM and the severity of coronary artery disease (CAD), and to assess the effect of ros...

The cholesterol metabolism is essential for cancer cell proliferation. We found the expression of genes involved in the cholesterol biosynthesis pathway up-regulated in the daunorubicin-resistant leukemia cell line CEM/R2, which is a daughter cell line to the leukemia cell line CCRF-CEM (CEM). Cellular (2)H2O labelling, mass spectrometry, and isotopomer analysis revealed an increase in lanoster...

Introduction The aim of the present study was to evaluate and compare the compressive strength (CS) of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement when mixed with propylene glycol (PG). Methods and Materials Twenty four custom-made split molds with 5 holes in each were prepared. Molds were allocated into eight groups (n=15 holes) as follows: Groups 1,5: CEM and ...

Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. An important stressor associated with affective disorders is the experience of childhood emotional maltreatment (CEM). We investigated whether the interaction of NPY risk genotype and CEM would affect brain activation. From The Netherlands Study of Depression and...