Myelodysplastic syndromes (MDS) are myeloid clonal disorders presumably induced by genetic mutations in immature hematopoietic cells. According to the international prognostic scoring system (IPSS or IPSS-R), patients are classified into two groups: lower-risk MDS (LR-MDS) and higher-risk MDS (HR-MDS). A majority of LR-MDS patients manifest refractory cytopenias due to inefficient hematopoiesis...

Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates with poor survival in MDS. Conditional deletion of Msi2 in a mouse model of MDS results in a rap...

We study strong existence and pathwise uniqueness for stochastic differential equations in R with rough coefficients, and without assuming uniform ellipticity for the diffusion matrix. Our approach relies on direct quantitative estimates on solutions to the SDE, assuming Sobolev bounds on the drift and diffusion coefficients, and L bounds for the solution of the corresponding Fokker-Planck PDE,...

Although linear perfect diffusion primitives, i.e. MDS matrices, are widely used in block ciphers, e.g. AES, very little systematic work has been done on how to find “efficient” ones. In this paper we attempt to do so by considering software implementations on various platforms. These considerations lead to interesting combinatorial problems: how to maximize the number of occurrences of 1 in th...

By retrospectively analyzing 288 patients with de novo myelodysplastic syndrome (MDS), we sought to determine the prevalence and clinical characteristics of bone marrow eosinophilia and basophilia that were detected at presentation. Bone marrow eosinophilia and basophilia were defined as a differential count of each cell type exceeding 5.0% and 1.0%, respectively. Of 288 patients with MDS, 36 (...

Diagnosis of myelodysplastic syndromes (MDS) could be difficult. We explored the usefulness of the enumeration of maturing B-lineage precursors (hematogones) by multiparameter flow cytometric analysis in the diagnosis of MDS in bone marrow (BM) specimens. We evaluated 111 MDS, 120 non-MDS (most with cytopenias; control group 1), and 41 noncytopenic lymphoma staging BM (control group 2) specimen...

Group classification of systems of two coupled nonlinear reaction-diffusion equation with a diagonal diffusion matrix is carried out. Symmetries of diffusion systems with singular diffusion matrix and additional first order derivative terms are described.

Group classification of systems of two coupled nonlinear reaction-diffusion equation with a diagonal diffusion matrix is carried out. Symmetries of diffusion systems with singular diffusion matrix and additional first order derivative terms are described.