Curcumin, a specific secondary metabolite of Curcuma species, has potentials for a variety of beneficial health effects. It is nowadays used as a dietary supplement. Everolimus (EVL) is an immunosuppressant indicated for allograft rejection and cancer therapy, but with narrow therapeutic window. EVL is a substrate of P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4). This study investigate...

مادة آلی محلول رنگی (CDOM) مقیاس مهمی در سنجش کیفیت آب است. می‌توان اذعان کرد CDOM نور موجود لایه‌های را کاهش می‌دهد و فعالیت‌های بیولوژیکی فتوسنتز مختل می‌کند سرانجام، مانع رشد جمعیت فیتوپلانکتون‌‌هایی می‌شود که برای زنجیرة غذای آبزیان ضروری‌اند. بیشتر تحقیق‌هایی تا کنون به انجام رسیده، از طول موج خاصی اندازه‌گیری ضریب جذب استفاده شده است اما، این تحقیق، امکان گسترة‌ وسیعی باندهای طیف مرئی، تع...

The human Ena/Vasp-like (EVL) protein is considered to be a bifunctional protein, involved in both actin remodeling and homologous recombination. In the present study, we found that human EVL forms heat-stable multimers of circular single-stranded DNA (ssDNA) molecules in the presence of a type I topoisomerase in vitro. An electron microscopic analysis revealed that the heat-stable ssDNA multim...

Endoscopic variceal ligation (EVL) is the standard-of-care therapy for treating and preventing recurrence of acute esophageal variceal hemorrhage.1 EVL can also be used to prevent a patient’s first variceal bleeding episode, particularly in patients who have medium or large varices showing high-risk signs for bleeding or patients who are intolerant to β-blocker therapy.1-3 EVL has supplanted th...

Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however, functional differences among coexpressed profilin isoforms are not well defined. Here, we demonstrate that profilin-1 and profilin-2 differentially regulate membrane protrusion, motility, and invasion; these processes are promoted by profilin-1 an...

OBJECTIVE To compare and evaluate the cost and effectiveness of endoscopic variceal ligation (EVL) at emergency plus octreotide versus octreotide alone in the treatment of acute esophageal variceal bleeding in cirrhotic patients. METHODS Seventy-eight patients with active variceal bleeding under emergency endoscope, were assigned to two groups receiving either combined therapy of EVL at emerg...

As the zebrafish embryo undergoes gastrulation and epiboly, the cells of the enveloping layer (EVL) expand, covering the entire yolk cell. During the epiboly process, the EVL cells move as a coherent layer, remaining tightly attached to each other and to the underlying yolk syncytial layer (YSL). In view of the central role of the actin cytoskeleton, in both cell motility and cell-cell adhesion...

PurposeThe mechanistic target of rapamycin inhibitors (mTORi), sirolimus (SRL) and everolimus (EVL), play a useful role in preventing or slowing progression cardiac allograft vasculopathy, however, they are poorly tolerated, sometimes requiring change between agents to other therapies. Current literature surrounding conversion mTORi incongruent, thus this study was designed assess the concentra...

AIM to investigate the side effects and survival of endoscopic variceal ligation by using Indonesian Endoscopic Ligator versus Endoscopic Variceal Sclerotherapy. METHODS we studied the medical records and endoscopy reports of patients who underwent endoscopic variceal ligation (EVL) or endoscopic sclerotherapy (EST) from January 2003 until December 2006. EST was done using ethoxysclerol injec...