To understand complex regulatory processes in multicellular organisms, it is critical to be able to quantitatively analyze protein movement and protein-protein interactions in time and space. During Arabidopsis development, the intercellular movement of SHORTROOT (SHR) and subsequent interaction with its downstream target SCARECROW (SCR) control root patterning and cell fate specification. Howe...

To date, the tabular-based SCR (Software Cost Reduction) method has been applied mostly to the development of embedded control systems. This paper describes the successful application of the SCR method, including the SCR* toolset, to a di erent class of system, a COMSEC (Communications Security) device called CD that must correctly manage encrypted communications. The paper summarizes how the t...

BACKGROUND The early prediction of delayed graft function (DGF) would facilitate patient management after kidney transplantation. METHODS In a single-centre retrospective analysis, we investigated kinetic estimated GFR under non-steady-state conditions, KeGFR, in prediction of DGF. KeGFR(sCr) was calculated at 4h, 8h and 12h in 56 recipients of deceased donor kidneys from initial serum creati...

The human regulator of complement activation membrane cofactor protein (CD46) has recently been identified as an attachment receptor for most species B adenoviruses (Ads), including Ad type 3 (Ad3), Ad11, and Ad35, as well as species D Ad37. To characterize the interaction between Ad35 and CD46, hybrid receptors composed of different CD46 short consensus repeat (SCR) domains fused to immunoglob...

As today’s supply chain (SC) networks are globalized complex systems planning and optimizing SC processes is harder than ever. Unexpected deviations and disruptions can lead to devastating and far-reaching consequences. Hence, the management of SC risk (SCR) is of fundamental importance. The literature on SCR is, however, mostly of anecdotic nature; only few authors present empirical research. ...

In order to enhance the applications of SCR devices for deep-submicron CMOS technology, a novel SCR design with “initial-on” function is proposed to achieve the lowest trigger voltage and the highest turn-on efficiency of SCR device for effective on-chip ESD protection. Without using the special native device (NMOS with almost zero or even negative threshold voltage) or any process modification...

BACKGROUND Renal dysfunction predicts mortality in patients with cardiovascular disease. How renal dysfunction relates to hemodynamics and mortality in pulmonary arterial hypertension (PAH) remains unclear. METHODS AND RESULTS We performed a cohort study of 500 patients with World Health Organization group I PAH from 1982 to 2006 with data on demographics, comorbidities, medications, function...

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of in part through interaction its C-terminal SCR-19 and SCR-20 domains host cell-bound C3b anionic oligosaccharides. In solution, CFH forms small amounts oligomers, one self-association sites being SCR-16/20 domains. order to correlate function dimer formation occurrence rare disease-...

BACKGROUND Baseline serum creatinine (SCr) level is frequently not measured in clinical practice. The aim of this study was to investigate the effect of various methods of baseline SCr determination measurement on accuracy of acute kidney injury (AKI) diagnosis in critically ill patients. METHODS This was a retrospective cohort study. All adult intensive care unit (ICU) patients admitted at a...

Skin conductance responses (SCR) are increasingly analyzed with model-based approaches that assume a linear and time-invariant (LTI) mapping from sudomotor nerve (SN) activity to observed SCR. These LTI assumptions have previously been validated indirectly, by quantifying how much variance in SCR elicited by sensory stimulation is explained under an LTI model. This approach, however, collapses ...