NF-κB essential modulator (NEMO) is a kinase integral to the macrophage TNF-α pathway, which leads to the intracellular destruction of Mycobacteria species. Defects in the NEMO pathway result in spectrum of diseases, including but not limited to ectodermal dysplasia, Mendelian susceptibility to mycobacterial diseases, and incontinentia pigmenti. In addition, paucity of NEMO can lead to the inab...

Human NEMO (NF-κB essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKKα and IKKβ, forms the IκB kinase (IKK) complex, a key regulator of NF-κB pathway signaling. NEMO is an elongated homodimer comprising mostly α-helix. It has been shown that a NEMO fragment spanning residues 44-111, which contains the IKKα/β binding site, is structurally disorder...

BACKGROUND AND OBJECTIVES We recently demonstrated that direct antiglobulin titer (DAT) positive, blood group A or B newborns born to group O mothers had a high incidence of hyperbilirubinemia, attributable to increased hemolysis. We reanalyzed our data asking whether increasing DAT strength plays a modulating role in the pathophysiology of the hemolysis and hyperbilirubinemia. METHODS Data f...

Large-scale failures triggered by undesirable events such as natural disasters, massive power malfunction, and malicious attacks are attracting serious concerns in communication network infrastructure perspective. However, there have been few survivability strategy analyses in network mobility (NEMO) scenarios. To properly address this issue, this paper proposes two novel survivability strategi...

— IETF has proposed Mobile IPv6-based Network Mobility (NEMO) basic support protocol (BSP) to support network mobility. NEMO BSP inherits all the drawbacks of Mobile IPv6, such as inefficient routing path, single point of failure, high handover latency and packet loss, and high packet overhead. To address these drawbacks, we proposed an IP diversity-based network mobility management scheme call...

Network Mobility (NEMO) supports the movement of some part of network that a group of Mobile Nodes (MNs) or Mobile Routers (MRs) moves together. To support NEMO, the NEMO basic support protocol (NBSP) was proposed [1]. In the nested mobile network, however, the NBSP exhibits pinball routing problem. The More nesting level, the problem becomes more serious. In this paper, we propose a new NEMO m...

With current Network Mobility (NEMO) Basic Support, all communications to and from Mobile Network Nodes must go through the Mobile Router and Home Agent (MRHA) tunnel when the mobile network is away. This results in increased length of packet route and increased packet delay in most cases. To overcome these limitations, one might have to turn to Route Optimization (RO) for NEMO. This memo docum...

The NEMO-3 detector installed in the Modane Underground Laboratory (LSM, France) is running to search for neutrinoless double beta decay (ββ0ν) with an expected sensitivity for the effective Majorana neutrino mass down to 0.1 eV. New preliminary limits (90% CL), T 1/2 (ββ0ν) > 1.0 · 10 23 y (right-handed currents) and T 1/2 (ββ0ν) > 1.9 · 10 23 y (massive mechanism) were established analyzing 1...

Ectodermal dysplasia with immune deficiency (EDI) is an immunological and developmental disorder caused by alterations in the gene encoding NF-κB essential modulator (NEMO; also known as IκB kinase γ subunit [IKKγ]). Missense mutations in the gene encoding NEMO are associated with reduced signal-induced nuclear translocation of NF-κB proteins, resulting in defective expression of NF-κB target g...

BACKGROUND Crohn's disease is an autoimmune inflammatory disorder of the gastrointestinal tract and is characterized clinically by dysregulation of both pro-inflammatory and anti-inflammatory cytokine signaling networks. The function of the Crohn's disease protein, NOD2, highlights the biphasic nature of the pathology of Crohn's disease. NOD2 can both strongly activate and negatively attenuate ...