Proinflammatory cytokine-mediated pancreatic beta-cell dysfunction is a key pathological event in type I diabetes mellitus. Lisofylline (LSF), an anti-inflammatory agent, has been shown to protect pancreatic islets from IL-1 beta-induced inhibitory effects on insulin release. However, the mechanism of LSF action is not known. Increasing evidence suggests that the mitochondria play an important ...

Presented a method for quantizing the wideband line spectrum frequencies (LSF) with a specific class of near-ellipsoidal lattice codes referred to as “generalized Voronoi codes”. Optimization procedures are described with respect to a weighted mean-square error (WMSE). The lattices D16, RE16 or R 16 are applied to quantize the LSF with no frequency splitting. Results indicate that near-ellipsoi...

Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in promoting HCC. A small molecule inhibitor of LSF, Factor Quinolinone Inhibitor 1 (FQI1), significantly inhibited human HCC xenografts in nude mice without harming normal cells. Here we evaluated the efficacy of FQI1 and an...

The mouse ischemic hindlimb model is used widely for studying collateral artery growth (i.e., arteriogenesis) in response to increased shear stress. Nonetheless, precise measurements of regional shear stress changes along individual collateral arteries are lacking. Our goal is to develop and verify trans-illumination laser speckle flowmetry (LSF) for this purpose. Studies of defibrinated bovine...

Abstract The reaction of methane with oxygen from La 0.8 Sr 0.2 FeO 3-δ (LSF) and several LSF-Fe 2 O 3 configurations was studied in chemical looping mode. Shell core (Fe ) (four catalysts called CS-3, CS-4, CS-5 CS-6, over a range coverage), LSF mixed uniformly Fe (UM) (front) followed by (PIS) were packed tubular reactor. conducted at 900 °C weight hourly space velocity (g methane/g catalyst/...

Rapidly decoding the emotional content of a face is an important skill for successful social behavior. Several Event Related brain Potential (ERP) have indicated that emotional expressions already influence brain activity as early as 100 ms. Some studies hypothesized that this early brain response to fear depends on coarse-magnocellular inputs, which are primarily driven by Low Spatial Frequenc...

This paper presents a model-based method for coding the LSF parameters of LPC speech coders on a “long-term” basis, that is, beyond the usual 20–30 ms frame duration. The objective is to provide efficient LSF quantization for a speech coder with large delay but veryto ultra-low bit-rate (i.e., below 1 kb/s). To do this, speech is first segmented into voiced/unvoiced segments. A Discrete Cosine ...

The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF...

Composite electrodes were prepared by adding 40 wt % La0.8Sr0.2FeO3 (LSF) into porous yttria-stabilized zirconia (YSZ) and their performance was studied as a function of time and calcination temperature. X-ray diffraction (XRD) patterns of the LSF-YSZ composites indicated an expanded lattice parameter after calcination above 1523 K, suggesting that Zr reacted with the LSF to form a Zr-doped per...

We present a preliminary analysis of the line spread function (LSF) of the Cosmic Origins Spectrograph (COS) using FUV and NUV stellar spectra acquired during the SM4 Servicing Mission Observatory Verification (SMOV). Our results indicate that the on-orbit shape of the COS LSF with the HST optical telescope assembly (OTA) deviates from the profile measured in ground testing due to the appearanc...