BACKGROUND Increased left atrial diameter (LAD) is associated with elevated risk of atrial fibrillation (AF) and cardiovascular disease. Information is limited regarding the short- or long-term correlates of LAD. METHODS AND RESULTS We evaluated clinical correlates of LAD for a 16-year period in 4403 Framingham Study participants (mean age, 45 years; 52% women; median observations/participant...

PURPOSE Our aim was to determine whether there is a correlation between cross-sectional areas of the left main coronary artery (LMCA), left anterior descending artery (LAD), and circumflex artery (CX) in normal cases using coronary CT angiography. METHOD Examinations of 180 patients (119 men and 61 women) were selected among 2248 consecutive coronary CT angiography studies. Cross-sectional ar...

BACKGROUND Ventricle-to-coronary artery bypass (VCAB) is an experimental revascularization procedure that provides predominantly systolic instead of diastolic blood flow to a coronary artery. METHODS AND RESULTS In a pig model, a stent-based procedure (VSTENT) was developed to create a VCAB. After thoracotomy, a covered VSTENT was implanted between the left ventricle and the left anterior des...

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...

Nicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion in a beating canine model. A Doppler probe was placed around the left anterior descending coronary artery (LAD) and thermal diffusion microprobe was implanted i...

BACKGROUND Previous studies have shown that lesions in proximal left anterior descending coronary artery (LAD) may develop more restenosis after balloon angioplasty than lesions in other coronary segments. However, stenting seems to have reduced this gap. In this study, we compared outcomes of percutaneous coronary intervention (PCI) on proximal LAD versus proximal left circumflex (LCX) or righ...

Learning Analytics Dashboards (LAD) provide a means to leverage data to support learners, teachers, and counselors. This paper reports on an in-depth analysis of how learners interact with a LAD. N=1,406 first-year students in 12 different study programs were invited to use a LAD to support them in their transition from secondary to higher education. The LAD provides actionable feedback about f...

the hallmarks of leukocyte adhesion deficiency (lad) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. these molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. over las...

Precise quantification of plant nitrogen (N) nutrition status is essential for crop N management. The concept of critical N concentration (Nc) has been widely used for assessment of plant N status. This study aimed to develop a new winter wheat Nc dilution curve based on leaf area duration (LAD). Four field experiments were performed on different cultivars with different N fertilization modes i...