An anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute (MNI) (D. L. Collins et al., 1998, Trans. Med. Imag. 17, 463-468) was performed. The MNI single-subject main sulci were first delineated and further used as landmarks for the 3D definition of 45 anatomical volumes of interest (AVOI) in each hemisphere. ...

Genomic instability is a condition that may be associated with carcinogenesis and/or physiological disorders when genetic lesions are not repaired. Besides, wild, captive, and domesticated vertebrates exposed to xenobiotics, leading health due cytogenotoxicity. This chapter provides an overview of tests assess cytogenotoxicity based on micronuclei (MNi) formation. Bone marrow test (BmMNt), peri...

ABSTRACT In this work, photometric and spectroscopic analyses of a very low-luminosity Type IIb supernova (SN) 2016iyc have been performed. SN lies near the faint end among distribution similar supernovae (SNe). Given lower ejecta mass (Mej) low nickel (MNi) from literature, combined with lying end, one-dimensional stellar evolution models 9–14 M? zero-age main-sequence (ZAMS) stars as possible...

A group connectome of 20 subjects has been normalized into standard stereotactic (MNI) space. Data has been processed using the Gibbs' Tracking approach (Reisert et al., 2011) [11] and normalized into standard space using DARTEL (Ashburner, 2007) [1]. All data has been acquired within the scope of the study A. Horn, D. Ostwald, M. Reisert, F. Blankenburg, The structural-functional connectome an...

Abstract The 7-nitroindolinyl family of caging chromophores has received much attention in the past two decades. However, its uncaging mechanism is still not clearly understood. In this study, we performed state-of-the-art density functional theory calculations to unravel photo-uncaging entirety, and compared probabilities all plausible pathways. We found competition between a classical cycliza...

UNLABELLED Motor symptoms in Parkinson disease (PD) are caused by a loss of dopamine input from the substantia nigra to the striatum. Blockade of adenosine 2A (A(2A)) receptors facilitates dopamine D(2) receptor function. In phase 2 clinical trials, A(2A) antagonists (istradefylline, preladenant, and tozadenant) improved motor function in PD. We developed a new A(2A) PET radiotracer, (18)F-MNI-...

David R. Colman: 1949–2011 On June 1, 2011, David Colman, a renowned Neuroscientist, Director of the Montreal Neurological Institute (MNI), and a long-standing member of the editorial board of this journal, passed away unexpectedly following a recent illness. His death was a devastating loss to his family, to his associates and coworkers at the MNI, and to his many friends and colleagues in neu...