In this paper, we study the geometry of cone-offs CAT(0) cube complexes over a family combinatorially convex subcomplexes, with an emphasis on their Gromov-hyperbolicity. A first application gives direct cubical proof characterization (strong) relative hyperbolicity right-angled Coxeter groups, which is particular case result due to Behrstock, Caprace, Hagen and Sisto. second acylindrical C ′ (...