Most tumors are resistant to therapy by thymidylate synthase (TS) inhibitors due to their high levels of TS. Instead of inhibiting TS, we hypothesized that it was possible to use this enzyme to activate suicide prodrugs (deoxyuridine analogues) to more toxic species (thymidine analogues). Tumors with high levels of TS could be particularly sensitive to deoxyuridine analogues because they would ...

The discharge of copper ion (Cu(II)) into natural waters can lead to serious environmental and health problems; however, an abundantly porous hierarchical adsorbent, such as faujasite (FAU), rapidly remove unwanted Cu(II). In this research, a hierarchically structured, mesoporous (FAU) was fabricated from industrial-waste lithium-silicon powder (LSP), with the addition biochar graphene oxide (G...

s of Technical Presentations Johnson Education Center FAU Harbor Branch Fort Pierce, Florida

Esters reduce to form ethers and alcohols on contact with metal nanoparticles supported Brønsted acidic faujasite (M-FAU) that cleave C−O bonds by hydrogenation hydrogenolysis pathways. Rates selectivities for each pathway depend the identity (M=Co, Ni, Cu, Ru, Rh, Pd, Pt). Pt-FAU gives propyl acetate consumption rates up 100 times greater than other M-FAU catalysts provides an ethyl ether sele...

We report the synthesis and characterization, reaction kinetics, deactivation mechanism of a series catalysts with metallic nickel (Ni) molybdenum carbide (Mo2C) particles supported on zeolite Y (Ni-Mo2C/FAU) in methane steam reforming (MSR) at 850 °C. Despite low Ni loading 2.4 wt%, MSR Ni-Mo2C/FAU exhibits high activity stability, yet Ni-FAU is significant. Further investigations elucidate th...

Designing zeolites for medical applications is a challenging task that requires introducing new functionalities without altering the intrinsic properties such as morphology, crystallinity, colloidal stability, surface charge, and porosity. Herein, we present encapsulation of luminescent ruthenium-tris(2,2?-bipyridyl) complex in faujasite (FAU) zeolite nanocrystals (Ru(bpy)3-FAU) their use an in...