Homology-directed repair (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis. We have characterized the consequences of HDR deficiency on anaphase, using markers for incomplete chromosome separation: DAPI-bridges and Ultra-fine bridges (UFBs). We show that multiple HDR factors (Rad51, Brca2 and Brca1) are critical for complete chromosome separation during an...

Tone mapping of high dynamic range (HDR) images for realistic display is a commonly studied. However, scientific visualization of HDR image for analysis of scene luminance has much less attention. In this paper, we have presented and implemented a simple approach for the reproduction and visualization of the color information in HDR images. We attempt several simple color visualizing functions,...

Recent advances in high dynamic range (HDR) capturing and display technologies attracted a lot of interest to HDR imaging. Many issues that are considered as being resolved for conventional low dynamic range (LDR) images pose new challenges in HDR context. One of such issues is human visual attention, which has important applications in image and video compression, camera and displays manufactu...

PURPOSE To evaluated prognostic factors and impact of the quality of planning of high dose rate brachytherapy (HDR-BT) for patients with local or locally advanced prostate cancer treated with external beam radiotherapy (EBRT) and HDR-BT. METHODS AND MATERIALS Between 1997 and 2005, 209 patients with biopsy proven prostate adenocarcinoma were treated with localized EBRT and HDR-BT at the Depar...

In recent years, research on computational photography has reached important advances in the field of coded apertures for defocus deblurring. These advances are known to perform well for low dynamic range images (LDR), but nothing is written about the extension of these techniques to high dynamic range imaging (HDR). In this paper, we focus on the analysis of how existing coded apertures techni...

BACKGROUND Assessment of color disc photograph (C-DP) is affected by image quality, which decreases the ability to detect glaucoma. High-dynamic-range (HDR) imaging provides a greater range of luminosity. Therefore, the objective of this study was to evaluate the capability of ophthalmology residents to detect glaucoma using HDR-concept disc photography (HDR-DP) compared to C-DP. DESIGN Cross...

Human cytomegalovirus (HCMV) is a ubiquitous pathogen capable of causing life threatening consequences in neonates and immune-compromised individuals. HCMV inflicts site-specific double strand breaks (DSBs) in the cellular genome. DNA damage infliction raises the corollary question of virus modulation of DNA repair. We recently reported HDR was stimulated in wt human foreskin fibroblasts (HFFs)...

High-dose-rate (HDR) brachytherapy as monotherapy is a comparatively new brachytherapy procedure for prostate cancer. In addition to the intrinsic advantages of brachytherapy, including radiation dose concentration to the tumor and rapid dose fall-off at the surrounding normal tissue, HDR brachytherapy can yield a more homogeneous and conformal dose distribution through image-based decisions fo...

Human embryonic stem cells (hESCs) are used as platforms for disease study, drug screening and cell-based therapy. To facilitate these applications, it is frequently necessary to genetically manipulate the hESC genome. Gene editing with engineered nucleases enables site-specific genetic modification of the human genome through homology-directed repair (HDR). However, the frequency of HDR remain...