In Japan, herpes simplex encephalitis (HSE) has historically been fatal in approximately 30% of all reported cases. After the induction of acyclovir (ACV), however, the mortality rate has decreased to 7.1% (1), and HSE is now regarded as a treatable disease. However, the rate of poor outcome including moderate or severe sequelae still remains at 30-40% of HSE patients, despite standard ACV trea...

Proinflammatory cytokines, including IL-1beta and tumor necrosis factor-alpha (TNF-alpha), promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1 (VCAM-1) on hepatic sinusoidal endothelium (HSE). In this study, hepatic metastasis after intrasplenically injected mouse B16 melanoma (B16M) cells was reduced 84-95% in mice with null mu...

Chromopeptide siderophores (azotobactin 87-I and -II) were isolated from an iron deficient culture medium of Azotobacter vinelandii ATCC 12837 (= DSM 87). Their structures were elucidated by chemical degradation studies and spectroscopic methods, especially 2D-NMR-techniques. Total assignments of 1H-, 13C-, and 15N-resonances based on 2D-HOHAHA-, 1H/13C-HMQC-, 1H/13C-HMBC-, 1H/15N-HMQC/TOCSY-, ...

OBJECTIVE To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE). METHODS Retrospective analysis of 44 patients with polymerase chain reaction-proven HSE for the presence of a large panel of onconeuronal and synaptic receptor antibodies. The effect of patients' serum was studied in cultures of primary mouse hippo...

BACKGROUND Conventional health, safety and environment (HSE) are a widely used approach to enhance availability and efficiency of complex systems. The integrated HSEE system is defined however as integration of conventional HSE with ergonomics approach. The presented HSEE system introduces a unique, effective and systemic mechanism, which integrates the structure of the human and organizational...

The objective of this study is to design a fuzzy expert system for performance assessment of health, safety, environment (HSE) and ergonomics system factors in a gas refinery. This will lead to a robust control system for continuous assessment and improvement of HSE and ergonomics performance. The importance of this study stems from the current lack of formal integrated methodologies for interp...

Previous studies have demonstrated the anti-hypertensive effects of Hibiscus sabdariffa L. (HS) in both humans and experimental animals. To explore the mechanisms of the anti-hypertensive effect of the HS, we examined the effects of a crude methanolic extract of the calyces of HS (HSE) on vascular reactivity in isolated aortas from spontaneously hypertensive rats. HSE relaxed, concentration-dep...

Abstraet Wettabillty of southern pine veneers was judged by measuring the contact angles made by 36 phenol formaldehyde resins. Formulation of the resins was by factorial design. the molar ratios of sodium hydroxide to phenol being 0.4, 0.7, and 1.0, the levels of resin solids content in the reaction mixture 37, 40, and 43 percent, and the molar ratios of formaldehyde to phenol 1.6, 1.9, 2.2, a...

BACKGROUND We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (HSE) from its mimics. METHODS We reviewed all adult cases of encephalitis with TL abnormalities on magnetic resonance imaging (MRI) from the California Encephalitis Project. We evaluated the association be...