نتایج جستجو برای: عدد spad

تعداد نتایج: 16996  

2012
Yuki Maruyama Jordana Blacksberg Edoardo Charbon

In this paper we present a time-gated single-photon avalanche diode (SPAD) array, the first of its kind to be integrated with a newly developed time-resolved laser Raman spectrometer. Time-resolved Raman spectra from various highly fluorescent minerals were successfully observed using our SPAD array; these spectra were obscured by an overwhelming fluorescence background when measured using a tr...

Journal: :Proceedings of SPIE--the International Society for Optical Engineering 2013
Francesco Panzeri Antonino Ingargiola Ron R Lin Niusha Sarkhosh Angelo Gulinatti Ivan Rech Massimo Ghioni Sergio Cova Shimon Weiss Xavier Michalet

Single-molecule fluorescence spectroscopy of freely diffusing molecules in solution is a powerful tool used to investigate the properties of individual molecules. Single-Photon Avalanche Diodes (SPADs) are the detectors of choice for these applications. Recently a new type of SPAD detector was introduced, dubbed red-enhanced SPAD (RE-SPAD), with good sensitivity throughout the visible spectrum ...

2012
Day-Uei Li Simon Ameer-Beg Jochen Arlt David Tyndall Richard Walker Daniel R. Matthews Viput Visitkul Justin A. Richardson Robert K. Henderson

We have successfully demonstrated video-rate CMOS single-photon avalanche diode (SPAD)-based cameras for fluorescence lifetime imaging microscopy (FLIM) by applying innovative FLIM algorithms. We also review and compare several time-domain techniques and solid-state FLIM systems, and adapt the proposed algorithms for massive CMOS SPAD-based arrays and hardware implementations. The theoretical e...

Journal: :Optics letters 2011
Jordana Blacksberg Yuki Maruyama Edoardo Charbon George R Rossman

We incorporate newly developed solid-state detector technology into time-resolved laser Raman spectroscopy, demonstrating the ability to distinguish spectra from Raman and fluorescence processes. As a proof of concept, we show fluorescence rejection on highly fluorescent mineral samples willemite and spodumene using a 128×128 single-photon avalanche diode (SPAD) array with a measured photon det...

Journal: :World journal of pediatrics : WJP 2012
Steffen Berger Janine Rufener Peter Klimek Zacharias Zachariou Colette Boillat

BACKGROUND After resection of long-segment Hirschsprung's disease, severe perianal dermatitis (SPAD) may occur because of high stool frequency and elevated concentrations of fecal pancreatic proteases. We investigated prospectively the effect of potato-derived protease inhibitors (PPI) on skin conditions in children with postoperative SPAD. METHODS Four children (aged 12 to 24 months) with th...

2015
Marco López Helmuth Hofer Stefan Kück

A highly accurate method for the determination of the detection efficiency of a silicon single-photon avalanche diode (Si-SPAD) is presented. This method is based on the comparison of the detected count rate of the Si-SPAD compared to the photon rate determined from a calibrated silicon diode using a modified attenuator technique, in which the total attenuation is measured in two attenuation st...

2006
M. Mozaffari D. M. Oosterhuis J. S. McConnell N. A. Slaton E. Evans E. Gonias A. Bibi C. Kennedy

monly used instruments is a Minolta SPAD (soil plant analysis development) meter. The SPAD meter measures the difference in light absorption at 430 and 750 nm (Wood et al., 1992). The former is the transmittance peak for chlorophyl ‘a’ and ‘b’, and the latter is in the near-infrared region. The instrument converts the difference in light absorption at these two wavelengths into a numerical SPAD...

2017
Ivan Michel Antolovic Samuel Burri Claudio Bruschini Ron A. Hoebe Edoardo Charbon

sCMOS imagers are currently utilized (replacing EMCCD imagers) to increase the acquisition speed in super resolution localization microscopy. Single-photon avalanche diode (SPAD) imagers feature frame rates per bit depth comparable to or higher than sCMOS imagers, while generating microsecond 1-bit-frames without readout noise, thus paving the way to in-depth time-resolved image analysis. High ...

2016
Anthony Tsikouras Pietro Peronio Ivan Rech Nehad Hirmiz Jamal Deen Qiyin Fang

Current instruments used to detect specific protein-protein interactions in live cells for applications in high-content screening (HCS) are limited by the time required to measure the lifetime. Here, a 32 × 1 single-photon avalanche diode (SPAD) array was explored as a detector for fluorescence lifetime imaging (FLIM) in HCS. Device parameters and characterization results were interpreted in th...

2015
Edoardo Charbon

The appearance of miniaturized single-photon detectors has enabled massively parallel conversion of photons to digital signals that can be readily processed and/or transported with negligible losses. As a consequence, a new class of imaging sensors is emerging, known collectively as all-digital image sensors, for detection and processing of ultra-fast and complex photonic events, often present ...

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