DEVELOPMENTAL CONTEXT OF SPERM CELLS ........................................ 190 Structural Characterization ..................................................................... 190 Sperm Dimorphism and Preferential Fertilization .......................................... 191 ISOLATION OF SPERM CELLS ................................................................. 192 Technical Details and P...

Purpose: The majority of pancreatic cancers overexpress mesothelin (MSLN), which contributes to enhanced proliferation, invasion, and migration. However, the MSLN regulatory network is still unclear. Here, we investigated the regulation of a panel of tumorigenic factors and explored the potential of MSLNregulated miR-198 treatment in vivo. Experimental Design: The expression and functional regu...

Diabetic foot ulcers (DFUs) are a devastating complication of diabetes; one in four diabetics will develop non-healing chronic ulcer, which potentially leads to lower limb amputations. This globally escalating medical issue lacks approved pharmacologic options. We identified defective molecular switch DFUs; consequence dysregulated TGF-b signaling. The deleterious effect failure this is apparen...

Stroke is a leading cause of morbidity and mortality globally. Leonurine (also named SCM-198), a compound extracted from Herba leonuri, was effective on the prevention of various cardiovascular and brain diseases. The purpose of this study was to explore the possible therapeutic potential of SCM-198 against ischemia reperfusion injury and underlying mechanisms. In the in vivo transient middle c...

BACKGROUND MiR-198 has been considered as an inhibitor of cell proliferation, invasion, migration and a promoter of apoptosis in most cancer cells, while its effect on non-cancer cells is poorly understood. METHODS The effect of miR-198 transfection on HaCaT cell proliferation was firstly detected using Cell Count Kit-8 and the cell cycle progression was analyzed by flow cytometry. Using bioi...

This work introduces a biochar as novel catalyst prepared from the pistachio hull, and demonstrates its catalytic potential for degrading the reactive red 198 (RR198) dye in catalytic ozonation processes (COPs). The prepared pistachio hull biochar (PHB) was a macroporous, basic material with low specific surface area. PHB had the greatest catalytic potential at an optimal alkaline pH of 10. Sig...