The texture development in experimentally sheared aggregates of olivine was monitored as a function of increased water content and added melt. In dry samples, an alignment of {010} with the shear plane and <100> and <001> with the shear direction, respectively, was observed, consistent with intracrystalline glide on the (010)[100] and (010)[001] slip systems. Samples with high water content sho...

PURPOSE To evaluate the antifungal activity of amphotericin B (AmB) in a mouse model of systemic candidiasis following administration of a novel oral AmB formulation (iCo-010) that has been pre-exposed to tropical temperatures. METHODS Amphotericin B (AmB) was prepared as a 5 mg/mL dispersion in a mixture of Peceol, Gelucire 44/14 and VitE-TPGS 2,3 (iCo-010). The formulation was protected fro...

This paper considers two methods for pricing assets and examines the relations between them. The +rst method is based on the principle of no-arbitrage, which asserts that introduction of the new asset should not create an arbitrage in a market that was before arbitrage free. This condition is satis+ed by prices for the new asset between speci+c lower and upper limits, determined as the values o...

We develop a model to study the implications of a legal environment on the organization of software production. We show that contract enforcement a®ects the organizational mode (i.e., in-house versus outsourcing) of customized software development while copyright protection determines the introduction of package software. When copyright protection is weak, only customized software will be devel...

Standard economic analysis holds that labor market rigidities are harmful for job creation and typically increase unemployment. But many orthodox reforms of the labor market have proved di±cult to implement because of political opposition. For these reasons it is important to explain why we observe such regulations. In this paper I outline a theory of how they may arise and why they ̄t together...

Context. Observations with the Hinode spectro-polarimeter have revealed strong horizontal internetwork magnetic fields in the quiet solar photosphere. Aims. We aim at interpreting the observations by means of results from numerical simulations. Methods. Radiative MHD simulations of dynamo action by near-surface convection are analyzed with respect to the relation between vertical and horizontal...

Introduction Family studies support a genetic contribution to Behçet’s disease (BD), with a sibling recurrence-risk ratio of 1152. The class I MHC molecule, HLA-B*51 (B*51), is the strongest known genetic risk factor for BD, however the gene immediately centromeric to HLA-B, MICA, has also been implicated in BD. Because of strong linkage disequilibrium (LD) between HLA-B and MICA, their respect...