نتایج جستجو برای: ضریب تغییرات cov

تعداد نتایج: 158079  

Journal: :Journal of virology 2017
Wanbo Tai Yufei Wang Craig A Fett Guangyu Zhao Fang Li Stanley Perlman Shibo Jiang Yusen Zhou Lanying Du

Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-binding domain (RBD). The RBD contains critical neutralizing epitopes and serves as an important vaccine target. Since RBD mutations occur in different MERS-CoV isolates and antibody escape mutants, cross-neutralization of divergent MERS-CoV strains...

2017
Fares S. Al-Sehaibany

As of January 2016, 1,633 laboratory-confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection and 587 MERS-related deaths have been reported by the World Health Organization globally. Middle East Respiratory Syndrome Coronavirus  may occur sporadically in communities or may be transmitted within families or hospitals. The number of confirmed MERS-CoV cases among heal...

2016
Tetsu Matsukawa Takahiro Okabe Einoshin Suzuki Yoichi Sato

In section 4.2 of the paper, we compared the distribution modeling of GOG to other distributions. Below, we describe the details of the compared methods. The Mean, Cov and Gauss are global distribution descriptors of pixel features within each region. The Cov-ofCov, Cov-of-Gauss and GOG are hierarchical distribution descriptors. The Cov-of-Cov uses covariance matrix in both patch and region mod...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم کشاورزی و منابع طبیعی ساری - دانشکده منابع طبیعی 1392

چکیده یکی از عوامل اصلی در تغییر روند رژیم هیدرولوژیکی جریان رودخانه، تغییر کاربری در سطح حوزه است. تغییر کاربری اراضی به عنوان یکی از چالش های عمده در قرن بیست و یکم مطرح خواهد بود و برخی حتی اعتقاد به شدیدتر بودن تاًثیرات آن نسبت به پدیده تغییر اقلیم دارند. در این تحقیق با استفاده از مدل هیدرولوژیکی hec-hms، اثرات تغییر کاربری اراضی بر رژیم هیدرولوژیکی حوزه آبخیز لکشای نکارود استان مازندران...

Journal: :The Journal of infectious diseases 2014
Sudhakar Agnihothram Robin Gopal Boyd L Yount Eric F Donaldson Vineet D Menachery Rachel L Graham Trevor D Scobey Lisa E Gralinski Mark R Denison Maria Zambon Ralph S Baric

BACKGROUND Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality among 136 cases to date. Design of vaccines to limit the virus spread or diagnostic tests to track newly emerging strains requires knowledge of antigenic and serologic relationships between MERS-CoV and other CoVs. METHODS  Using synthe...

Journal: :PLoS ONE 2008
Bingke Bai Qinxue Hu Hui Hu Peng Zhou Zhengli Shi Jin Meng Baojing Lu Yi Huang Panyong Mao Hanzhong Wang

The pathogenesis of SARS coronavirus (CoV) remains poorly understood. In the current study, two recombinant baculovirus were generated to express the spike (S) protein of SARS-like coronavirus (SL-CoV) isolated from bats (vAcBS) and the envelope (E) and membrane (M) proteins of SARS-CoV, respectively. Co-infection of insect cells with these two recombinant baculoviruses led to self-assembly of ...

2015
Yaseen Arabi Hanan Balkhy Ali H. Hajeer Abderrezak Bouchama Frederick G. Hayden Awad Al-Omari Fahad M. Al-Hameed Yusri Taha Nahoko Shindo John Whitehead Laura Merson Sameera AlJohani Khalid Al-Khairy Gail Carson Thomas C. Luke Lisa Hensley Abdulaziz Al-Dawood Saad Al-Qahtani Kayvon Modjarrad Musharaf Sadat Gernot Rohde Catherine Leport Robert Fowler

As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use of convalescent plasma (CP) has been suggested as a potential therapy based on existing evidence from other viral i...

Journal: :Journal of clinical pathology 2005
S C C Wong J K C Chan K C Lee E S F Lo D N C Tsang

AIMS To develop a quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) for severe acute respiratory syndrome coronavirus (SARS-CoV) detection and explore the potential of using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control to exclude false negative results. METHODS SARS-CoV and GAPDH mRNA were both measured in 26 specimens from 16 patients wit...

2011
Marta L. DeDiego Jose L. Nieto-Torres Jose M. Jiménez-Guardeño Jose A. Regla-Nava Enrique Álvarez Juan Carlos Oliveros Jincun Zhao Craig Fett Stanley Perlman Luis Enjuanes

Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, g...

Journal: :Scientific reports 2016
Vincent J Munster Danielle R Adney Neeltje van Doremalen Vienna R Brown Kerri L Miazgowicz Shauna Milne-Price Trenton Bushmaker Rebecca Rosenke Dana Scott Ann Hawkinson Emmie de Wit Tony Schountz Richard A Bowen

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have focused on two potential reservoirs: bats and camels. Here, we investigated the role of bats as a potential reservoir for MERS-CoV. In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus j...

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