Fro Ba Ve Mo Kin Dr an ex con com rel Ma OBJECTIVES This study assessed whether the benefit of sacubtril/valsartan therapy varied with clinical stability. BACKGROUND Despite the benefit of sacubitril/valsartan therapy shown in the PARADIGM-HF (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial, it has been suggested that switch...

Conflictos de interés: MP es investigador principal en estudios clínicos auspiciados por MSD, Sanofi-Aventis, AstraZeneca, Novartis Biosciences, Roche y Phenomix Corporation; miembro del Advisory Board de Sanofi-Aventis del Perú; conferenciante para Sanofi-Aventis del Perú, Novartis Biosciences y BristolMyers Squibb; ha recibido auspicio para asistir a eventos científicos por Sanofi-Aventis del...

a From the Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, ON, Canada b Department of Medicine, University of Toronto, Toronto, ON, Canada c Department of Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE d Novartis Horsham Research Centre, Horsham, West Sussex, England e Novartis Pharmaceuticals, East H...

1 Marine Biomedical and Biotechnology Research Program, Harbor Branch Oceanographic Institute, Florida Atlantic University, 5600 US 1 North, Fort Pierce, FL 34946, USA; E-Mails: [email protected] (G.K.); [email protected] (A.E.W.) 2 Novartis Institutes for BioMedical Research, Developmental & Molecular Pathways, Novartis Pharma AG, WSJ-355.1.051.21, Fabrikstrasse 22, Basel CH-4056, Switzer...

Biozentrum, University of Basel, CH-4056 Basel, Switzerland; Helmholtz Zentrum München, Institute of Stem Cell Research, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany; Instituto Cajal, CSIC, Avda Dr Arce 37, E-28002 Madrid, Spain; Neurodegeneration Department, Neuroscience Research, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland 5 present address: Novartis Pha...

Cover image: immunofluorescence staining of tTG (green) and tTG activity (red) in a brain blood vessel of the APP23 Alzheimer mouse model as used in Chapter 5. APP23 mice are originally from healthcare company Novartis. Image printed with permission of Novartis. Chapter images: immunofluorescence stainings of collagen (green) in culture plates after removal of cells, as described in Chapter 4.

Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, 3000 Bern 60, Switzerland PET Center, Division of Nuclear Medicine, University Hospital, 8091 Zurich, Switzerland Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, 8093 Zurich, Switzerland Novartis Institutes f...