OBJECTIVE Current disease activity measures for systemic lupus erythematosus (SLE) are difficult to score or interpret and problematic for use in clinical practice. Lupus Foundation of America (LFA)-Rapid Evaluation of Activity in Lupus (REAL) is a pilot application composed of anchored visual analogue scores (0-100 mm each) for each organ affected by lupus. This study evaluated the use of LFA-...

Amongst the different clinical and laboratory parameters used to Background: monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. The aim of this study was to Methods: evaluate ...

INTRODUCTION/OBJECTIVE Evaluate the quality of life (QOL) of women with systemic lupus erythematosus (SLE) and the association between QOL domains, measured by the World Health Organization Quality of Life Group (WHOQOL-100) assessment instrument, and disease activity. PATIENTS AND METHODS A cross-sectional analytic study involving 95 patients with SLE, according to the American College of Rh...

Objetives. To determine the correlation between prolactin levels and disease activity classified based on Mexican lupus erythematosus systemic index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well manifestations of active were determined. Disease was evaluated using Systemic Lupus Erythematosus Activity Index (MEX-S...

UNLABELLED BACKGROUND Incidence and disease pattern of childhood-onset SLE is reported to differ among ethnic groups. METHODS To describe disease pattern and 6 month follow-up in a referral based cohort of 45 Vietnamese children with SLE. Forty-five children who were subsequently diagnosed to have systemic lupus erythematosus (f/m = 4/1) were referred to the Ho Chi Minh City Children's Hos...

INTRODUCTION Autoantibodies against C1q correlate with lupus nephritis. We compared titers of anti-C1q and anti-dsDNA in 70 systemic lupus erythematosus patients with (n = 15) or without (n = 55) subsequent biopsy-proven lupus nephritis. METHODS The 15 patients with subsequent lupus nephritis had anti-C1q assays during clinical flares (mean Systemic Lupus Erythematosus Disease Activity Index ...

OBJECTIVE Anti-ribosomal P antibodies (aRib-P Ab) are highly specific for systemic lupus erythematosus (SLE), but their correlatation with disease activity and manifestations including renal, hepatic and central nervous system (CNS) involvement is still controversial. The aim of our study was to evaluate the prevalence of aRib-P Ab and their correlation with clinical manifestations and anti-dsD...

OBJECTIVE To test the interrater and intrarater reliability of the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) Responder Index (SRI-50), an index designed to measure ≥ 50% improvement in disease activity between visits in patients with systemic lupus erythematosus. METHODS This was a multicenter, cross-sectional study with raters from Canada, the United Kingdom, and A...

AIM To evaluate the correlation between the levels of CD4, CD8 and CD25 cells and SLE disease in active phase and in remission. METHODS A total of 25 SLE patients, aged between 18-60 years, and fulfilling the ACR criteria with preferential Renal and CNS involvement were included in this study. Baseline CD4/CD8 and CD25 counts, lab parameters etc were conducted. Approximately at the end of 6 m...