نتایج جستجو برای: شاخص ed50

تعداد نتایج: 76082  

Journal: :Investigative ophthalmology & visual science 1977
W D Gibbons R G Allen

The maculae of rhesus monkeys were exposed to an argon-ion lazer operated in the TEM00 continuous wave mode at a wavelength of 514.5 nm. Both ophthalmoscopic and histopathologic evaluations of exposure sites were obtained. Threshold (ED50) values were obtained for 0.5, 5, 30, 120, and 1,000 sec. exposure times. Presence of minimum visible lesions was assessed ophthalmoscopically at both 1 hour ...

Journal: :British journal of anaesthesia 1999
M Irifune M Sugimura T Takarada K Maeoka Y Shimizu T Dohi T Nishikawa M Kawahara

We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent manner with an ED50 value of 140 (95% confidence limits 123-160) mg kg-1 (n = 40; eight animals per dose, five doses per dose-response curve). The ED50 for propofol decreased sign...

Journal: :Journal of bacteriology 1961
W E WICK F STREIGHTOFF D H HOLMES

The 50 per cent effective or curative dose (ED50 or CD50) of a new chemotherapeutic agent against bacterial infections in mice is generally used to determine the efficacy of this agent as compared to that of established antibiotics. Although many of the ED50 values of these antibiotics are found in publications, a comprehensive summary of these data is not available. This communication is desig...

Journal: :Antimicrobial agents and chemotherapy 2009
Kenji Kurokawa Hiroshi Hamamoto Miki Matsuo Satoshi Nishida Noriko Yamane Bok Luel Lee Kazuhisa Murakami Hideki Maki Kazuhisa Sekimizu

The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the parental strain-mediated killing of larvae. Changes in MICs and ED50 of other antibiotics were negligible, ...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
G Perrault R Depoortere E Morel D J Sanger B Scatton

Amisulpride, a benzamide derivative, is an antipsychotic drug with a pharmacological profile distinct from that of classical neuroleptics such as haloperidol and from that of another benzamide, remoxipride. In mice, amisulpride antagonized hypothermia induced by apomorphine, quinpirole or (+/-) 7-hydroxy-2-(di-n-propylamino)-tetralin, an effect involving D2/D3 receptors, at similar doses (ED50 ...

Journal: :Organic & biomolecular chemistry 2015
Zong-Jie Gan Yu-Hua Wang Yun-Gen Xu Ting Guo Jun Wang Qiao Song Xue-Jun Xu Shi-Yuan Hu Yu-Jun Wang De-Chuan Wang De-Zhu Sun Di Zhang Tao Xi Hao-Dong Li Hai-Bo Zhang Tai-Jun Hang Hong-Guo Lu Jing-Gen Liu

A novel series of 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline derivatives maj-3a-maj-3u were synthesized and evaluated in vitro for their binding affinity at κ-opioid receptors. Maj-3c displayed the highest affinity for κ-opioid receptors (Ki = 0.033 nM) among all the compounds evaluated. Furthermore, all four stereoisomers of compound 3c were prepared, and...

Journal: :The Journal of General Physiology 1990
H H Valdivia R Coronado

The agonist effect of the dihydropyridine (DHP) (-)Bay K 8644 and the inhibitory effects of nine antagonist DHPs were studied at a constant membrane potential of 0 mV in Ca channels of skeletal muscle transverse tubules incorporated into planar lipid bilayers. Four phenylalkylamines (verapamil, D600, D575, and D890) and d-cis-diltiazem were also tested. In Ca channels activated by 1 microM Bay ...

Journal: :Anesthesiology 2018
Amanda H Klein Husam K Mohammad Rabiah Ali Brad Peper Steven P Wilson Srinivasa N Raja Matthias Ringkamp Sarah Sweitzer

BACKGROUND The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. It was predicted that viral vector delivery of a combination of genes encoding the µ-opioid receptor and preproenkephalin would attenuate neuropathic pain and enhance opioid ...

Journal: :Swiss medical weekly 2011
Li-Hua Hang Dong-Hua Shao Yue-Ping Gu

OBJECTIVE Various research programmes have shown that intraoperative infusion of remifentanil has been associated with postoperative hyperalgesia. Previous studies have demonstrated that low-dose ketamine can inhibit central sensitisation and prevent opioid-induced hyperalgesia (OIH). However, the optimal ketamine dose to prevent OIH has not been determined. In the present study we aimed to det...

Journal: :British journal of anaesthesia 1995
M Naguib A H Samarkandi H S Bakhamees M A Magboul A K el-Bakry

We have determined the relative potency of rocuronium, pancuronium, pipecuronium and vecuronium, and examined the nature of the interaction of rocuronium with the other three steroidal neuromuscular blocking drugs. We studied the dose-response relationships of each drug and their combination with rocuronium in 200 ASA I or II patients during propofol-fentanyl-nitrous oxide-oxygen anaesthesia. N...

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