Coronary artery disease (CAD) is a common health problem with a high rate of disability and death. Dyslipidemia and altered metabolism of Apo-lipoproteins are involved in the CAD pathogenesis. The current study investigated two common polymorphisms (rs429358 and rs7412) and promoter DNA methylation status of APOE in the Iranian CAD patients and control subjects. Two hundred angiographi...

the adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (cad). the inflammatory enzyme, myeloperoxidase (mpo) also has an important role in the pathogenesis of cad. association of the adipokines with mpo remains to be resolved in patients with cad. in this case-control study, 100 patients with cad and 100 control subjects were appropriately r...

coronary artery disease (cad) is the number one killer of adults in the iran. fibrinogen is cad risk factor that participation in both the atherogenic and thrombogenic processes. also playing a role in thrombosis and atherogenesis is homocysteine, as a risk factor for cad. long-term exercise training and physical activity favorably modified several of the conventional cad risk factors. no such ...

Coronary artery disease (CAD) including myocardial infarction (MI) as its complication, is one of the most common heart diseases worldwide and also in Iran, with extremely elevated mortality. CAD is a multifactorial disorder. Twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of CAD. Many studies have reported a significant...

Background: Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of ADIOPQ gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM). Methods: Genotypes of two SNPs we...

background and aims: bilirubin has been considered an antioxidant that protects against atherosclerosis. the aim of this study was to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (cad) and long-term outcome in the patients undergoing primary percutaneous coronary intervention (pci). materials and methods: this prospective cohort ...

cardiovascular disease has become the main factor of death and birth defects in the world and also in iran. new clinical studies have shown that early diagnosis of patients with coronary artery disease (cad) can contribute to effective prevention or therapeutic structures, which reduce mortality or the next chance of cardiovascular events, and increase the quality of life. most studies on cad d...