Bortezomib (BTZ) is a reversible proteasome inhibitor. It affects NF-κB activity and has shown clinical efficacy in multiple myeloma. However, the same mechanisms through which it curtails malignant growth may compromise antitumor immunity. As dendritic cells (DC) play a vital role in the elicitation and maintenance of antitumor immunity, we studied the long-term effects of BTZ on human DC deve...

We study the dynamical behavior of the BTZ(Banados-Teitelboim-Zanelli) black hole with the low-energy string effective action. The perturbation analysis around the BTZ black hole reveals a mixing between the dilaton and other fields. Introducing the new gauge(dilaton gauge), we disentangle this mixing completely and obtain one decoupled dilaton equation. We obtain the decay rate Γ of BTZ balck ...

The T-cell lymphoproliferative neoplasms (T-LPN) are characterized by a poor clinical outcome. Current therapeutics are mostly non-selective and may induce harmful side effects. It has been reported that NOTCH1 activation mutations frequently associate T-LPN. Because anti-Notch1 based therapies such as γ-secretase inhibitors (GSI) are less efficient and induce considerable side effects, we hypo...

A novel CuBi2O4 consisting of self-assembled spherical nanocolumn arrays (CuB-H) was synthesized via a facile hydrothermal method. It was further modified by controlling the Cu:Bi ratio during synthesis to become an efficient bi-functional catalyst (CuB-2.5) activate persulfate (PS) and peroxymonosulfate (PMS) for 1H-benzotriazole (BTZ) removal. Characterization of CuB-2.5 using XRD, 10 FESEM, ...

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells in the bone marrow leading to bone destruction and bone marrow failure. Several molecular mechanisms underlie chemoresistance among which heme oxygenase-1 (HO-1) could play a major role. The aim of the present research was to evaluate the impact of HO-1 in MM following bortezomib (BTZ) tr...

We introduce a set of scalar fields as test fields to study the dynamical behaviors of the BTZ(Banados-Teitelboim-Zanelli) black hole. These include minimally coupled scalar, conformally coupled scalar, and dilaton. To calculate the decay rate of the BTZ black hole, we consider both the Dirichlet boundary condition at spatial infinity and the matching procedure. It turns out that the dilaton is...

The greybody factors for spin 1 2 particles in the BTZ black holes are discussed from 2D CFT in bulk-boundary correspondence. It is found that the initial state of spin 1 2 particle in the BTZ black holes can be described by the Poincaré vacuum state in boundary 2D CFT, and the nonlinear coordinate transformation causes the thermalization of the Poincaré vacuum state. For special case, our resu...

Primary effusion lymphoma (PEL) is a rare form of aggressive B cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Current chemotherapy approaches result in dismal outcomes, and there is an urgent need for new PEL therapies. Previously, we established, in a direct xenograft model of PEL-bearing immune-compromised mice, that treatment with the proteasome inhibitor, bortezomib...

This paper has two parts. First we review the description of local bulk operators in Lorentzian AdS in terms of non-local operators in the boundary CFT. We discuss how bulk locality arises in pure AdS backgrounds and how it is modified at finite N . Next we present some new results on BTZ black holes: local operators can be defined inside the horizon of a finite N BTZ black hole, in a way that ...