Type 1 Gaucher disease (GD), a non-neuronopathic lysosomal storage disorder, results from the deficient activity of acid beta-glucosidase (GBA). Type 1 disease is panethnic but is more prevalent in individuals of Ashkenazi Jewish (AJ) descent. Of the causative GBA mutations, N370S is particularly frequent in the AJ population, (q approximately .03), whereas the 84GG insertion (q approximately ....

Consider rolling a die with k sides, labeled a1, a2, ..., and ak, respectively. Let P(aj) be the ‘probability’ that a particular side aj appears after rolling the die. Before attempting to calculate P(aj), it is necessary to clarify the meaning of the word ‘probability’. In other words, we must specify what the number P(aj) quantifies. In statistics, the concept of ‘probability’ is formally int...

To elucidate the origin and evolution of mannan-binding lectins (MBL), a new C-type lectin (CTL) specific for high-mannose glycans (MBL-AJ) was isolated from the coelomic plasma of the holothurian Apostichopus japonicus. MBL-AJ has oligomeric forms with identical 17-kDa subunits on SDS-PAGE. Among natural ligands, lectin hemagglutination activity was competitively inhibited by extracellular low...

Two of our principal results (in a simplified form) are as follows. theorem For p prime, the number of solutions of the equation c1a1 + · · · + ckak = λ, aj ∈ Aj , where cj ∈ F×p and λ ∈ Fp are fixed coefficients, and the variables aj range over sets Aj ⊆ Fp, does not exceed the number of solutions of the equation a1 + · · · + ak = 0, aj ∈ Āj , where the variables aj range over arithmetic progr...

This review will examine the possibilities for providing anaesthesia for casualties in challenging situations.There is a limited evidence base on which to draw as most anaesthetists faced with such problems will generate their own solution based on experience and personal preference. Military personnel are perhaps more likely to encounter these challenges and may be trained anaesthetists or jun...

Data-centric synchronization advocates data-based synchronization as opposed to control-based synchronization. It is more intuitive and can make correct concurrent programming easier. Dolby et al. [9] proposed AJ, a type system for data-centric synchronization, and showed that Java programs can be refactored into AJ. Unfortunately, programmers still have to add synchronization constructs manual...

Let H°°(Dn) denote the set of all bounded analytic functions defined on the polydisc D" of Cn. In this note, we give a sufficient condition for sequences of points in £>" to be interpolating sequences for H°°(Dn). We also discuss some conditions for interpolation of general domains. Let G(X) be the set of all bounded continuous functions on a compact set X and let A C C(X) be a uniform algebra ...

Families A1, ...,Ak of sets are said to be cross-intersecting if Ai ∩ Aj 6= ∅ for any Ai ∈ Ai and Aj ∈ Aj , i 6= j. A nice result of Hilton that generalises the Erd®sKo-Rado (EKR) Theorem says that if r ≤ n/2 and A1, ..., Ak are cross-intersecting sub-families of ( [n] r ) , then

Under certain assumptions we show that a wavelet frame {τ(Aj , bj,k)ψ}j,k∈Z := {|detAj |−1/2ψ(A−1 j (x− bj,k))}j,k∈Z in L2(Rd) remains a frame when the dilation matrices Aj and the translation parameters bj,k are perturbed. As a special case of our result, we obtain that if {τ(Aj , ABn)ψ}j∈Z,n∈Zd is a frame for an expansive matrix A and an invertible matrix B, then {τ(Aj , ABλn)ψ}j∈Z,n∈Zd is a ...

Let e > 1 and b > 2 be integers. For a positive integer n = ∑k j=0 aj × b j with 0 6 aj < b, define