This paper compares student learning in challenge-based and traditional engineering classrooms from the perspective of adaptive expertise. Collaborating learning scientists and biomedical engineers designed and implemented a challenge-based method of instruction that followed learning principles presented in the National Research Council report “How People Learn” (HPL). The study was conducted ...

We have established a stable human cell line, termed HPL-A3, by co-transfection of a human pregnane X receptor (hPXR) expression vector and a reporter plasmid (p3A4-hPXRE-Luc) containing a luciferase gene and a promoter/enhancer region of the human cytochrome P450 3A4 (CYP3A4) gene into a human hepatoma-derived cell line, HepG2. We then examined the usefulness of HPL-A3 for a chemically activat...

BACKGROUND As individuals live a longer life, health-promoting lifestyle (HPL) becomes even more essential, particularly with regard to maintaining functional independence and improving quality of life (QoL). OBJECTIVES This study aimed to determine the association between QoL and HPL in the Iranian elderly living in Shiraz. MATERIALS AND METHODS This analytical cross-sectional study was co...

The silk gland of Bombyx mori (BmSG) has gained significant attention by dint of superior synthesis and secretion of proteins. However, the application of BmSG bioreactor is still a controversial issue because of low yields of recombinant proteins. Here, a 3057 bp full-length coding sequence of Hpl was designed and transformed into the silkworm genome, and then the mutant (Hpl/Hpl) with specifi...

Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications. Characterization of alternative media formulations is imperative for MSC therapeutic application. Human BMMSC and AdMSC were expanded in media sup...

Probes derived from clones bearing cDNAs corresponding to the alpha subunit of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) were used to localize their respective mRNAs cytologically in sections of first trimester and term human placenta . hPL mRNA was exclusively localized to the syncytial layer; hCGa mRNA was found in the syncytial layer and also in some differentiati...

Dermal fibroblasts have been used clinically to promote wound healing and reduce wrinkles. Most of the time, fetal bovine serum (FBS) is for expansion fibroblasts. In addition, chemically defined medium can also be fibroblast expansion. Nonetheless, both FBS are not ideal culture cells that will as has risk pathogen transmission induction xenogeneic immune response whilst extremely expensive. t...

Probes derived from clones bearing cDNAs corresponding to the alpha subunit of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) were used to localize their respective mRNAs cytologically in sections of first trimester and term human placenta. hPL mRNA was exclusively localized to the syncytial layer, hCG alpha mRNA was found in the syncytial layer and also in some different...

The spr2 mutation in tomato (Solanum lycopersicum), which disrupts function of FATTY ACID DESATURASE 7 (FAD7), confers resistance to the potato aphid (Macrosiphum euphorbiae) and modifies the plant’s C6 volatile profiles. To investigate whether C6 volatiles play a role in resistance, HYDROPEROXIDE LYASE (HPL), which encodes a critical enzyme in C6 volatile synthesis, was silenced in wild-...

Background and Objective: The young adults, especially the students of medical fields, as the health ambassadors of every community, play a vital role in health maintenance and improvement of society. Promoting the lifestyle behaviors of this group leads to the better health status of other society members. This study was set to asses the Lealth-promoting Lifestyle (HPL) of medical students in ...