Bax inhibitor-1 (BI-1) is an anti-apoptotic gene whose expression is upregulated in a wide range of human cancers. Studies in both mammalian and plant cells suggest that the BI-1 protein resides in the endoplasmic reticulum and is involved in the unfolded protein response (UPR) that is triggered by ER stress. It is thought to act via a mechanism involving altered calcium dynamics. In this paper...

هدف: با توجه به رشد روزافزون آموزش شیوه مجازی و ویژه در شرایط گسترش پاندمی کرونایروس، نقش اساسی مدیریت کلاسی ارتقا کیفیت باید مورد قرار گیرد این پژوهش هدف تدوین مدل رابطه علّی هدفمند کلاس وضعیت روان‌شناختی پیامدهای تحصیلی دانشجویان انجام شد. روش: روش بر حسب هدف، کاربردی ماهیت از نوع توصیفی - همبستگی بود. جامعه آماری مشتمل انواع مقاطع دانشگاه­ های دولتی پیام نور شهر تهران نمونه اساس جدول مورگان ب...

In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4) which belonged to a branch of the UPR, the [protein kinase RNA (PKR)-like ER kinase, (PERK)]-[eukaryotic initiation factor 2 subunit alpha (eIF2α)...

Valproic acid (VPA) is a clinically available histone deacetylase inhibitor with promising anticancer attributes. Recent studies have demonstrated the anticancer effects of VPA on prostate cancer cells. However, little is known about the differential effects of VPA between metastatic and non-metastatic prostate cancer cells and the relationship between the expression of metastasis suppressor pr...

Antimicrobial peptides represent an expanding family of peptides involved in innate immunity of many living organisms. They show an amazing diversity in their sequence, structure, and mechanism of action. Among them, plant defensins are renowned for their antifungal activity but various side activities have also been described. Usually, a new biological role is reported along with the discovery...

Image deblurring or signal restoration can be formulated as a data fitting least squares problem, but the problem is found to be ill-posed and regularization is needed, hence introducing the need to find a regularization parameter. We study the properties of the regularized least squares functional ‖Ax− b‖2Wb + ‖D(x− x0)‖ 2 Wx for the solution of discretely ill-posed systems of equations. It wa...

اواسط شهریور 1401 و در نزدیکی ساحل ماسه‌ای رودخانۀ نکا شمال ایران، به روش تورزدن روی گل‌آذین بوته‌های کاهوک (.Lactuca serriola L) میان تمشک وحشی (.Rubus idaeus انار (.Punica granatum L)، نمونه‌ای جیرجیرک جمع‌آوری شد که بررسی توسط کلیدهای شناسایی شکل‌شناسی مقایسه با نمونه‌های از قبل تعیین نام شدۀ موزۀ حشرات هایک میرزایانس رکورد جدید جنس گونه را تایید کرد. این اولین گزارش گونۀ Arachnocephalus ves...