Introduction: After anterior cruciate ligament (ACL) injury, potential copers (PCs) and non-copers (NCs) are differentiated based on functional ability and knee stability. Due to frequent episodes of the knee giving way, rehabilitation specialists recommend NCs undergo ACL reconstruction (ACLR) prior to the resumption of sport activities. Some PCs opt to have non-operative management while othe...

An interval type-2 TSK fuzzy logic system can be obtained by considering the membership functions of its existed type-1 counterpart as primary membership functions and assigning uncertainty to cluster centers, standard deviation of Gaussian membership functions and consequence parameters. In many cases it has been difficult to determine the spread percentages for these parameters to obtain an o...

OBJECTIVE Systemic sclerosis (SSc) is an autoimmune disease clinically manifesting as progressive fibrosis of the skin and internal organs. Cadherin-11 (CDH11) expression is increased in fibrotic skin and lung tissue. Targeting CDH11 may be an effective approach to treating fibrosis. We hypothesize that targeting CDH11 will decrease fibrosis in the tight skin-1 (Tsk-1) mouse model. METHODS CD...

Three classes of signaling molecule, VG1, WNT and BMP, play crucial roles in axis formation in the chick embryo. Although VG1 and WNT signals have a pivotal function in inducing the primitive streak and Hensen's node in the embryo midline, their action is complemented by that of BMP antagonists that protect the prospective axial tissue from the inhibitory influence of BMPs secreted from the per...

In this work, the conformational space of the pseudosaccharyl ether 3-(allyloxy)-1,2-benzisothiazole 1,1-dioxide (ABID) has been studied by means of infrared spectroscopy and density functional theory (DFT) calculations. Five different low energy conformers (TSk, TC, GSk, GSk' and GC, with relative energies of 0.00, 1.97, 2.00, 3.82 and 6.02 kJ mol(-1), respectively) were found on the DFT(B3LYP...

OBJECTIVE To assess the factor structure of the Chinese version of the Tampa Scale for Kinesiophobia (TSK). DESIGN Chinese patients with chronic pain attending either orthopaedic specialist services (n = 216) or multidisciplinary specialist pain services (n = 109) participated in this study. METHODS Subjects completed the Chinese version of TSK, The Chronic Pain Grade Questionnaire, Hospita...

The Wnt signaling pathway is essential for the development of diverse tissues during embryogenesis. Signal transduction is activated by the binding of Wnt proteins to the type I receptor low-density lipoprotein receptor-related protein 5/6 and the seven-pass transmembrane protein Frizzled (Fzd), which contains a Wnt-binding site in the form of a cysteine-rich domain. Known extracellular antagon...

Through sequence-based classification, this paper tries to accurately predict the DNA binding sites of transcription factors (TFs) in an unannotated cellular context. Related methods in the literature fail to perform such predictions accurately, since they do not consider sample distribution shift of sequence segments from an annotated (source) context to an unannotated (target) context. We, th...

This study aimed to identify the skin temperature (Tsk) behavior to understand the acute cross-effect after unilateral training of lower-limbs. Seventeen healthy young men (weight, 75.2±5.5 kg; height, 1.8±0.1 m; age, 22.5±1.6 years) were divided into two groups: high-trained (n=8) and low-trained (n=9). All participants performed: (a) one-repetition maximum (1RM) testing protocol on the leg pr...