نتایج جستجو برای: روش eso
تعداد نتایج: 373201 فیلتر نتایج به سال:
How the immune system recognizes endogenously arising tumors and elicits adaptive immune responses against nonmutated tumor-associated Ags is poorly understood. In search of intrinsic factors contributing to the immunogenicity of the tumor-associated Ag NY-ESO-1, we found that the NY-ESO-1 protein binds to the surface of immature dendritic cells (DC), macrophages, and monocytes, but not to that...
PURPOSE Although NY-ESO-1 was isolated from an esophageal carcinoma patient, its expression in this type of cancer and its immunogenicity in esophageal cancer patients have not yet been fully elucidated. We report here the frequency of NY-ESO-1 mRNA and protein expression in esophageal cancer and the presence of NY-ESO-1-specific immune response in patients. EXPERIMENTAL DESIGN One hundred tw...
Existential second-order logic (ESO) and monadic second-order logic (MSO) have attracted much interest in logic and computer science. ESO is a much more expressive logic over word structures than MSO. However, little was known about the relationship between MSO and syntactic fragments of ESO. We shed light on this issue by completely characterizing this relationship for the prefix classes of ES...
Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-4 therapy on human immune responses is still unclear. To explore this, we analyzed immune-related adverse events and immune responses in metastatic...
We have shown previously that HLA-A*0201 melanoma patients can frequently develop a CTL response to the cancer testis antigen NY-ESO-1. In the present study, we have analyzed in detail the relative antigenicity and in vitro immunogenicity of natural and modified NY-ESO-1 peptide sequences. The results of this analysis revealed that, although suboptimal for binding to the HLA-A*0201 molecule, pe...
Due to the high homology between the LAGE-1 and NY-ESO-1 proteins, we hypothesized that an anti-NY-ESO-1 vaccine might elicit LAGE-1 immunity and hence may be effective in multiple myeloma (MM) patients with LAGE-1-positive/NY-ESO-1-negative tumors. Therefore, we set out to evaluate LAGE-1 and NY-ESO-1 mRNA and protein expression in MM patients in a bid to evaluate possible benefits of their ho...
در سال های اخیر با پیشرفت تکنولوژی کامپیوتر، روش های جدید بهینه سازی سازه ها پدید آمده اند. از بین این روش ها، روش بهینه سازی تکاملی سازه ها (eso) به خاطر سادگی آن همیشه مطرح بوده است. در این پژوهش سعی داریم از روش eso جهت تعیین مقاطع بهینه در قاب خمشی فولادی استفاده کنیم. هدف، طراحی بهینه قاب فولادی (حداقل کردن وزن) در عین حال ارضاء معیارهای آیین نامه می باشد. یافتن طرح بهینه نیاز به تکرار های...
سازه های فضاکار از جمله سازه های سه بعدی با شکل خاص می باشند. اغلب سازه های فضاکار را می توان به شبکه ها، گنبدها و چلیک ها دسته بندی کرد. شبکه دولایه یک مثال کلاسیک در رابطه با سازه های فضاکار به حساب می آید. با پیشرفت ابزارهای محاسباتی و افزایش سرعت کامپیوترهای پیشرفته، برای ارائه یک محصول قابل رقابت، بحث بهینه سازی یک ابزار لازم الاجرا در پروسه طراحی به حساب می آید. عموماً بهینه سازی سازه ها م...
NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in ...
Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer pa...
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