The effect of 2’-cytidylic acid and 3’qtidylic acid upon the binding of cupric ions by RNase has been studied by gel filtration, together with the effect of cupric ions upon binding of 2’and 3’-cytidylic acids. The results confirm that binding of 2’-CMP by RNase weakens its athnity for cupric ions; reciprocally, binding of cupric ion diminishes the athnity of RNase for 2’CMP. The negative inter...

The terminal sugar sialic acid (Sia) plays a pivotal role in cell-cell interaction and recognition. A prerequisite for the biosynthesis of sialoglycoconjugates is the activation of Sia to cytidine monophosphate-Sia (CMP-Sia), by CMP-Sia synthetases (CMP-Sia-syn). CMP-Sia-syn are conserved from bacteria to man, and have been found to reside in the nucleus of all vertebrate species analysed to da...

Infants diagnosed with allergy to cow's milk protein (CMP) are fed extensively hydrolysed cow's milk formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed rice protein infant formulas have become available and have been shown to be well tolerated by these infants. A prospective open, randomized clinical study to compare the clinical tolerance of a new hydrolysed rice pro...

The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD2 and CD14, but not MR. These TLR4 reporter cells also express an NF-κB-dependent, secreted embryonic alkaline phosphatase (SEAP) reporter gene. TL...

We have used monoclonal antibodies against cell-surface developmental epitopes in combination with micromagnetic beads to isolate phenotypically defined subpopulations of cholangiocyte marker-positive fetal liver epithelial cells (CMP-FLEC). Differentiation potential was evaluated by injecting cell isolates from dipeptidyl peptidase IV (DPPIV) positive (DPPIV+) Fischer donor rats into the splee...

In many-core CMP architectures, the cache coherence protocol is a key component since it can add requirements of area and power consumption to the final design and, therefore, it could restrict severely its scalability. Area constraints limit the use of precise sharing codes to smallor medium-scale CMPs. Power constraints make impractical to use broadcast-based protocols for large-scale CMPs. T...

Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been...

Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs. Previous kinetic data using recombinant or highly purified human UMP/CMP kinase showed that dCMP, as well as pyrimi...

SpĂĄnkovĂŠ poruchy dĂ˝chania predstavujĂş vĂ˝znamnĂ˝ rizikovĂ˝ faktor cerebrovaskulĂĄrnych ochorenĂ­. SyndrĂłm spĂĄnkovĂŠho apnoe (SAS) je u pacientov s cievnou mozgovou prĂ­hodou (CMP) častĂ˝ a nepriaznivo ovplyvňuje ich zdravotnĂ˝ stav. Napriek tomu ostĂĄva veÄžkĂĄ časĹĽ CMP po tejto strĂĄnke nediagnostikovanĂ˝ch prichĂĄdza o potenciĂĄlny benefit pretlakovej ventilačnej liečby. V tomto Ä...