BACKGROUND Concurrent chemoradiation therapy (CCRT) and transoral laser microsurgery (TLM) have become therapeutic selections for organ preservation in patients with hypopharyngeal cancer. METHODS Our cross-sectional, observational study assesses quality of life (QOL) in patients with hypopharyngeal cancers receiving TLM plus radiotherapy (RT) compared with those treated with CCRT only or rad...

With the evolution of Electronic System Level (ESL) design methodologies, we are experiencing an extensive use of Transaction-Level Modeling (TLM). TLM is a high-level approach to modeling digital systems where details of the communication among modules are separated from the those of the implementation of functional units. This paper represents a first step toward the automatic insertion of te...

یکی از فناوری‌های سازه‌ای بسیار خلاقانه در معماری اسلامی ایران گنبدهای دوپوستة گسستة نار هستند که پوستة درونی، بیرونی، گریو، و معمولاً خشخاشی‌ نشکیل شده‌اند. این میان، خشخاشی‌ها عناصر آجری فضای میان دو گنبد ساخته طرح‌‌ها ترکیب‌های متنوع، ویژگی‌های ساختمانی پیچیده، نیز مشکلات دسترسی به پوسته برای مطالعة باعث شده ابهامات زیادی دربارة آن‌ها پیش روی ما باشد. فقدان تعریفی جامع مانع مطالعات پیشین خشخا...

Actor-oriented modeling approaches are convenient for implementing functional models of embedded systems. Architectural models for heterogeneous system-on-chip architectures, however, are usually implemented using transaction level modeling (TLM). Even though both modeling paradigms, actor-oriented design and TLM, can conveniently be implemented using a common language such as SystemC, a method...

OBJECTIVE For early glottic carcinoma, the 2 main treatment modalities are radiotherapy (RT) and transoral CO2 laser microsurgery (TLM). The aim of this study was to investigate treatment preferences and considerations in patients with early glottic carcinoma (T1-T2) who were given a choice between TLM and RT. SUBJECTS AND METHODS Patients with early glottic cancer (suspected or confirmed ext...

Recent years have witnessed much progress in computational modelling for protein subcellular localization. However, the existing sequence-based predictive models demonstrate moderate or unsatisfactory performance, and the gene ontology (GO) based models may take the risk of performance overestimation for novel proteins. Furthermore, many human proteins have multiple subcellular locations, which...

Transaction-level modeling (TLM) is a methodology for building models at high levels of abstraction, those above RTL. TLM-2.0 is a library that contains classes that implements a methodology for building transaction-level models in systemC and connecting them together. It was developed by OSCI and released in 2009 and is now on its way to becoming an IEEE standard as part of IEEE-1666-2011. In ...

The design of embedded computing systems faces great challenges due to the huge complexity of these systems. The design complexity grows exponentially with the increasing number of components that have to cooperate properly. One solution to address the complexity problem is the modeling at higher levels of abstraction. However, it is generally not clear which features to abstract (and to what e...

In recent years, surgical treatment of laryngeal cancer has evolved towards transoral resections. Transoral laser microsurgery (TLM) combines microscopic control with the precise cutting and coagulation capability that laser equipment has, making it possible to remove laryngeal tumours by the transoral approach, with very good oncological and functional outcomes. In early tumours, local control...