background: maternal mortality (mm) is an avoidable death andthere is national, international and political commitment to reduceit. the objective of this study is to examine the relation of mm tosocioeconomic factors and its inequality in iran’s provinces at anecologic level.methods: the overall mm from each province was considered for3 years from 2004 to 2006. the five independent variables wh...

Control 16 Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline MMR 15 Saline Saline Saline Saline MMR MMR Saline Saline Saline Saline Saline Saline Saline Saline Saline TCV 12 Hep B Hep B Hep B Hep B Saline Saline DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib 1990s Primate 12 Hep B Hep B Hep B Hep B MMR MMR DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib...

Midgut malrotation (MMR) is a congenital anomaly referring to either nonrotation or incomplete rotation of the primitive intestinal loop around the axis of the superior mesenteric artery during fetal development. Adult MMR is rare and majority of MMR in adults remains asymptomatic throughout life. The increasing use of diagnostic imaging for acute abdominal pain will lead to more incidental rec...

This study focused on the question of how the DNA mismatch repair (MMR) system and p53 interact to maintain genomic integrity in the presence of the mutagenic stress induced by hydrogen peroxide (H(2)O(2)). The cytotoxic and mutagenic effects of H(2)O(2) were compared in four colon carcinoma sublines: HCT116, HCT116/E6, HCT116+ch3, and HCT116+ch3/E6, representing MMR(-)/p53(+), MMR(-)/p53(-), M...

Vibration energy harvesting technology can capture ambient forms. Using an shock absorber (EHSA) is one of the methods to achieve this function. The EHSA with mechanical motion rectifier (MMR) has bifurcation, which improve performance and reduce impact between gears. However, bifurcation makes it difficult quantitatively predict vibrational dissipation MMR−EHSA. Evaluating MMR−EHSA during desi...

Kristen rat sarcoma viral oncogene homolog (KRAS) and microsatellite instability (MSI) are prognostic markers of colorectal cancer (CRC). However, the clinical value is still not fully understood, when giving the consideration to both the molecular makers. Five hundred fifty-one patients with CRC were retrospectively assessed by determining their clinicopathological features. KRAS mutations wer...

Previous studies in our laboratory have described increased and preferential radiosensitization of mismatch repair-deficient (MMR(-)) HCT116 colon cancer cells with 5-iododeoxyuridine (IUdR). Indeed, our studies showed that MMR is involved in the repair (removal) of IUdR-DNA, principally the G:IU mispair. Consequently, we have shown that MMR(-) cells incorporate 25% to 42% more IUdR than MMR(+)...

AIM Some retrospective studies have shown a lack of benefit of 5-fluorouracil (5-FU) adjuvant chemotherapy in patients with mismatch repair (MMR) deficient colorectal cancer. Our aim was to assess if this molecular marker can predict benefit from 5-FU adjuvant chemotherapy. A second objective was to determine if MMR status influences short term survival. METHODS We included 754 patients with ...

Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR. The MMR capability must be limited to a post-replicative temporal window during which the signals are available. However, both identity of the signal(s) involved in the retention of this temporal window and the mechanism that maintains the...

Mismatch Repair (MMR) is closely linked to DNA replication; however, other than the role of the replicative sliding clamp (PCNA) in various MMR functions, the linkage between DNA replication and MMR has been difficult to investigate. Here we use an in vitro DNA replication system based on simian virus 40, to investigate MMR recruitment to replicating DNA. Both DNA replication and MMR proteins a...