The multi-functional NS1 protein of influenza A virus is a viral virulence determining factor. The last four residues at the C-terminus of NS1 constitute a type I PDZ domain binding motif (PBM). Avian influenza viruses currently in circulation carry an NS1 PBM with consensus sequence ESEV, whereas human influenza viruses bear an NS1 PBM with consensus sequence RSKV or RSEV. The PBM sequence of ...

A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major determinant of virulence. Elimination of SARS-CoV E protein PBM by using reverse genetics caused a reduction in the deleterious exacerbation of the immun...

HYPOTHESIS Pancreaticobiliary maljunction (PBM) is a high-risk factor for biliary tract carcinogenesis because of a continuous reflux of pancreatic juice into the biliary tract. It remains to be disclosed whether we should perform prophylactic excision of gallbladders and bile ducts. DESIGN A person-year method. SETTING A university hospital. PATIENTS We studied 68 patients with PBM treat...

previous results indicated that performance of chicks fed a high level (10%) of poultry by-product meal(pbm) was lower than performance of chicks fed a corn-soybean meal (sbm) diet. the latter difference was hypothesized to be due to variation in digestible amino acid (aa) levels among the diets. this study evaluated diets containing pbm formulated on equivalent total aa basis vs. an equivalent...

Anaemia and allogeneic blood transfusions in surgical patients are associated with poor outcomes. Patient blood management (PBM) has been developed as an evidence-based clinical tool, by which clinicians can optimise anaemia, manage peri-operative bleeding, avoid unnecessary blood transfusion and improve patient outcome. This article aims to highlight the recent updates regarding evidence-based...

Peak bone mass (PBM) is has been defined as: (1) the maximum bone mass attained in adulthood; (2) the amount of bone acquired when bone gain ceases; and the BMD during the plateau that follows growth and bone mass accrual and precedes the bone loss that occurs later in adulthood. These definitions lead to different approaches for identifying PBM. Most commonly, PBM has been defined based on cro...

PURPOSE To identify the genes and noncoding RNAs (ncRNAs) involved in the neuroprotective actions of a dietary antioxidant (saffron) and of photobiomodulation (PBM). METHODS We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12 h 5 lux, 12 h darkness) were challenged by 24 h exposure to bright (1,000 lux) light....

BACKGROUND Moderate to severe intraoperative bleeding and the presence of acquired coagulopathy remain serious problems in the management of major pediatric craniosynostosis surgery. After implementation of a ROTEM(®) -assisted patient blood management (PBM) strategy, using primarily purified coagulation factor concentrates, feasibility and costs of this new regimen were analyzed. METHODS Ret...

A 60-day feeding trial was conducted to evaluate the potential of using poultry by-product meal (PBM) as a partial replacement for fish meal (FM) in the diets for juvenile sobaity. Six iso-nitrogenous and iso-lipidic diets were formulated to contain graded levels of PBM, at 0 (as control diet), 15, 25, 35, 45, and 55% of FM replacement. Each diet was fed to groups of 20 juvenile sobaity in trip...

HTLV-1 cellular transformation and disease induction is dependent on expression of the viral Tax oncoprotein. PDZ is a modular protein interaction domain used in organizing signaling complexes in eukaryotic cells through recognition of a specific binding motif in partner proteins. Tax-1, but not Tax-2, contains a PDZ-binding domain motif (PBM) that promotes the interaction with several cellular...