Motivation: Whole genome sequencing is becoming a diagnostics of choice for the identification of rare inherited and de novo copy number variants in families with various pediatric and late-onset genetic diseases. However, joint variant calling in pedigrees is hampered by the complexity of consensus breakpoint alignment across samples within an arbitrary pedigree structure. Results: We have dev...

Parvalbumin-positive (PV) basket cells provide perisomatic inhibition in the cortex and hippocampus and control generation of memory-related network activity patterns, such as sharp wave ripples (SPW-R). Deterioration of this class of fast-spiking interneurons has been observed in neuropsychiatric disorders and evidence from animal models suggests their involvement in the acquisition and extinc...

This study aimed at assessing the effect of nitrogen addition under two forms, nitrate and ammonium, on the stabilization of Zn, Pb, and Cd by Populus euramericana Dorskamp grown in contaminated soils for 35 days under controlled conditions. Temporal changes in the soil pore water (SPW) were monitored for pH, dissolved organic carbon (DOC), and total dissolved concentrations of metals in the so...

Under the influence of a wiggler magnetic field, phenomenon second harmonic generation at metal–semiconductor interface, induced by surface plasma wave (SPW), has been investigated. Metals like Cu, Ag, and Al, each with thin layer n-InSb over it, are considered for our study. Laser light is incident on metal layered glass prism in attenuated total reflection Kretschmann configuration (ATR), whi...

While walking, human beings continuously adjust step length (SpL), step time (SpT), step speed (SpS = SpL/SpT) and step width (SpW) by integrating both feedforward and feedback mechanisms. These motor control processes result in correlations of gait parameters between consecutive strides (statistical persistence). Constraining gait with a speed cue (treadmill) and/or a rhythmic auditory cue (me...

In this paper we present evidence that important systematic errors, owing to the light beam imperfections, account for the anomalous decrease of the calculated values of the film thickness as a function of the wavelength in the near infrared. In the Kretschmann and Raether configuration /1//2/ (prism/thin metal film/vacuum), a Surface Plasma Wave (SPW) can be excited at the metal/vacuum interfa...

Learning and other cognitive tasks require integrating new experiences into context. In contrast to sensory-evoked synaptic plasticity, comparatively little is known of how synaptic plasticity may be regulated by intrinsic activity in the brain, much of which can involve nonclassical modes of neuronal firing and integration. Coherent high-frequency oscillations of electrical activity in CA1 hip...

According to a two-stage memory consolidation model, during waking theta states, afferent activity from the neocortex to the hippocampus induces transient synaptic modification in the hippocampus, where the information is deposited as a labile form of memory trace. During subsequent sharp-wave ripples (SPW-Rs), the newly acquired hippocampal information is transferred to the neocortex and store...

This paper proposes a power saving mechanism with variable sleep period to reduce the power consumed by optical network units (ONUs) in passive optical network (PON) systems. In the PON systems based on time division multiplexing (TDM), sleep and periodic wake-up (SPW) control is an effective ONU power saving technique. However, the effectiveness of SPW control is fully realized only if the sle...

Processing bias is an important feature of substance abuse. The issue whether processing bias is a more or less permanent feature of nicotine addiction remains to be resolved. The present study addresses the role of smoking status on smoking-related processing bias. We employed Event-Related Brain Potentials (ERPs) as measure of processing bias to investigate this issue. Further, self-report me...