The idea of exploiting Global Sensitivity Analysis (GSA) to make Evolutionary Algorithms more effective seems very attractive: intuitively, a probabilistic analysis can prove useful to a stochastic optimisation technique. GSA, that gathers information about the behaviour of functions receiving some inputs and delivering one or several outputs, is based on computationally-intensive stochastic sa...

delta-Aminolevulinic acid (ALA), the universal biosynthetic precursor of tetrapyrrole pigments, is synthesized from glutamate in plants, algae, and many bacteria via a three-step process that begins with activation by ligation of glutamate to tRNA(Glu), followed by reduction to glutamate-1-semialdehyde (GSA) and conversion of GSA to ALA. The GSA aminotransferase step requires no substrate other...

UNLABELLED The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. METHODS Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPE...

The new AASHTO Mechanistic-Empirical Pavement Design Guide (MEPDG) performance predictions for the anticipated climatic and traffic conditions depend on the values of the numerous input parameters that characterize the pavement materials, layers, design features, and condition. This paper proposes comprehensive local sensitivity analyses (LSA) and global sensitivity analyses (GSA) methodologies...

UNLABELLED Small-animal models are crucial to gain insights in the complex recovery mechanisms of liver function during liver regeneration. (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) has been introduced for noninvasive assessment of liver function in the clinical setting as well as in experimental research. However, HBS is restricted to planar modalities in small animals because hepati...

Student school engagement, or the person-environment fit between a student and the student’s school, is a construct that has received increasing attention in the school psychology literature in recent years. However, little research has examined this construct among lesbian, gay, bisexual, transgender, queer and questioning (LGBTQ) students or analyzed whether factors such as access to safe adu...

The concept of intelligently controlling the search process of gravitational search algorithm (GSA) is introduced to develop a novel data mining technique. The proposed method is called fuzzy GSA miner (FGSA-miner). At first a fuzzy controller is designed for adaptively controlling the gravitational coefficient and the number of effective objects, as two important parameters which play major ro...

Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) is a liver scintigraphy agent which binds to asialoglycoprotein receptor in hepatocyte. Twenty-six patients with liver dysfunction were examined with 99mTc-GSA liver scintigraphy using two-compartment and two-parameter model (2C2P model). The 99mTc-GSA was assumed to move within two compartments (whole ...

Data clustering is one of the most popular techniques of information management, which is used in many applications of science and engineering such as machine learning, pattern reorganization, image processing, data mining, and web mining. Different algorithms have been suggested by researchers, where the evolutionary algorithms are the best in data clustering and especially in big datasets. It...

The objective of this paper is to propose three modified versions of the Gravitational Search Algorithm for continuous optimization problems. Although the Gravitational Search Algorithm is a recently introduced promising memory-less heuristic but its performance is not so satisfactory in multimodal problems particularly during the later iterations. With a view to improve the exploration and exp...