نتایج جستجو برای: خطبه 221
تعداد نتایج: 8849 فیلتر نتایج به سال:
Giriş: Obstrüktif uyku apne sendromu (OUAS) ve bronş hiperreaktivitesi (BHR) arasındaki ilişki iyi bilinmemektedir. Bu çalışmada, OUAS’lı hastalarda hastalığın şiddeti ve BHR arasındaki ilişkiyi araştırdık. Materyal ve Metod: Bu çalışmaya polisomnografileriyle OUAS tanısı alan 47 (37’si erkek, 10’u kadın) hasta alındı. Histamin provokasyon testi yapıldı ve beden kitle indeksi (BKİ, kg/m2) hesap...
« خطبۀالبیان »نام یکی از خطبه های منسوب به مولا علی (ع) است که درباره صحت انتساب آن به امام در طول تاریخ دیدگاه های مختلفی وجود داشته است . در این خطبه کلماتآغاز می شود و به شرح حال ایشان به « اَنَا » مسجعی بر زبان حضرت جاری شده که با ضمیرعنوان ولی و انسان کامل در حالت فنای فی الله اشاره دارد . از این رو، این خطبه بهشطحیات اهل تصوف شباهت دارد و همواره از یک سو مورد توجه صوفیان و فرقه هایشیعه و ب...
Increasing evidence suggests that lineage specific subpopulations and stem-like cells exist in normal and malignant breast tissues. Epigenetic mechanisms maintaining this hierarchical homeostasis remain to be investigated. In this study, we found the level of microRNA221 (miR-221) was higher in stem-like and myoepithelial cells than in luminal cells isolated from normal and malignant breast tis...
MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma
MiR-221 is frequently upregulated in papillary thyroid cancer (PTC) tissues and cell lines, and this study was designed to validate the association of miR-221 with PTC proliferation, apoptosis, and migration. We observed that miR-221 suppressed TIMP3 expression by binding to 3' untranslated region of TIMP3 mRNA, and TIMP3 expression was increased with the presence of miR-221 inhibitors; TIMP3 s...
به منظور فهم بهتری از خطبه جهاد در نهج البلاغه ،در این مطالعه به تحلیل و بررسی آن از منظر زبانشناسی و بر اساس فرانقش بینافردی دستور نفش گرای نظام مند هلیدی پرداخته شده است. بدین منظور ابتدا تمامی صد بند خطبه مذکور تجزیه شد بطوریکه عناصر ساختار وجهی (فاعل و جزء خودایستا)از عناصر باقیمانده بند تفکیک شود. با توجه به تعریف ویژه فاعل در این دیدگاه، بررسی ها نشان داد که اعتبار تعداد زیادی از بندهای ا...
microRNA miR-221 is frequently over-expressed in a variety of human neoplasms. Aim of this study was to identify new miR-221 gene targets to improve our understanding on the molecular tumor-promoting mechanisms affected by miR-221. Gene expression profiling of miR-221-transfected-SNU-398 cells was analyzed by the Sylamer algorithm to verify the enrichment of miR-221 targets among down-modulated...
Glioblastoma is the most common type of primary brain tumor in adults, with high mortality and morbidity rates. More effective therapeutic strategies are imperative. Previous studies have shown that the known p110-β-selective inhibitor TGX-221 blocks the activation of PKB/Akt in PTEN-deficient cells. We treated U87 and U251 glioblastoma cells with TGX-221 to determine the effect of TGX-221. We ...
A rising body of evidence suggests that silencing microRNAs (miRNAs) with oncogenic potential may represent a successful therapeutic strategy for human cancer. We investigated the therapeutic activity of miR-221/222 inhibitors against human multiple myeloma (MM) cells. Enforced expression of miR-221/222 inhibitors triggered in vitro anti-proliferative effects and up-regulation of canonic miR-22...
MicroRNA-221 and microRNA-222 (miR-221/222) have been identified as oncogenes and confirmed to be overexpressed in various types of cancer. However, the regulation mechanism of miR-221/222 in oral squamous cell carcinoma (OSCC) remains to be fully elucidated. Previously, an miR-221/222 sponge was successfully constructed and its effect on the downregulation of miR-221/222 expression was investi...
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